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| Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study | |
| Sun, Xiaohui1; Ye, Ding1; Du, Lingbin2,3,4; Qian, Yu1; Jiang, Xia5,6; Mao, Yingying1 | |
| 2020-08-12 | |
| Source Publication | INTERNATIONAL JOURNAL OF CANCER
 |
| ISSN | 0020-7136 |
| Corresponding Author | Jiang, Xia(xia.jiang@ki.se) ; Mao, Yingying(myy@zcmu.edu.cn) |
| Abstract | Inflammation is considered to play a pivotal role in the pathogenesis of cancer, and observational studies have reported a relationship between circulating inflammation markers and the risk of prostate cancer. Using summary data of >140 000 individuals, two-sample Mendelian randomization (MR) analyses were performed to evaluate whether circulating levels of 27 cytokines and growth factors have a causal effect on the risk of developing prostate cancer. Genetically predicted elevated levels of monocyte chemotactic protein-1 (MCP-1) were associated with an increased risk of prostate cancer (odds ratio (OR) per 1 SD increase = 1.06, 95% confidence interval (CI): 1.04-1.09) at Bonferroni-adjusted level of significance (P < 1.85 x 10(-3)). Results were stable across sensitivity analyses, and there was no evidence of directional pleiotropy. Under MR assumptions, our findings suggested a risk-increasing effect of circulating MCP-1 levels on prostate cancer. Whether targeting MCP-1 or its downstream effectors are useful in reducing prostate cancer incidence needs further investigation. |
| Keyword | cytokines inflammation Mendelian randomization monocyte chemotactic protein-1 prostate cancer |
| DOI | 10.1002/ijc.33221 |
| WOS Keyword | HEPATOCYTE GROWTH-FACTOR ; PROTEIN-1 MCP-1 ; CHEMOKINE ; VARIANTS ; POLYMORPHISMS ; EXPRESSION ; MIGRATION ; EPIDEMIOLOGY ; INFLAMMATION ; PROGRESSION |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Foundation of Zhejiang Chinese Medical University[2020ZR09] ; Foundation of Zhejiang Chinese Medical University[KC201905] ; National Natural Science Foundation of China[81602917] ; National Natural Science Foundation of China[81973663] ; Natural Science Foundation of Zhejiang Province[LQ20H260008] ; Talent Project of Zhejiang Association for Science and Technology[2018YCGC003] |
| Funding Organization | Foundation of Zhejiang Chinese Medical University ; National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province ; Talent Project of Zhejiang Association for Science and Technology |
| WOS Research Area | Oncology |
| WOS Subject | Oncology |
| WOS ID | WOS:000558419000001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.hfcas.ac.cn:8080/handle/334002/102910 |
| Collection | 中国科学院合肥物质科学研究院 |
| Corresponding Author | Jiang, Xia; Mao, Yingying |
| Affiliation | 1.Zhejiang Chinese Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou 310053, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Dept Canc Prevent, Beijing, Peoples R China 4.Zhejiang Canc Hosp, Dept Canc Prevent, Hangzhou, Zhejiang, Peoples R China 5.Karolinska Inst, Ctr Mol Med, S-17177 Stockholm, Sweden 6.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA |
| Recommended Citation GB/T 7714 | Sun, Xiaohui,Ye, Ding,Du, Lingbin,et al. Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study[J]. INTERNATIONAL JOURNAL OF CANCER,2020. |
| APA | Sun, Xiaohui,Ye, Ding,Du, Lingbin,Qian, Yu,Jiang, Xia,&Mao, Yingying.(2020).Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study.INTERNATIONAL JOURNAL OF CANCER. |
| MLA | Sun, Xiaohui,et al."Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study".INTERNATIONAL JOURNAL OF CANCER (2020). |
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