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EGFR exon 20 insertion mutations in non-small cell lung cancer | |
Wang, Fenfang1,2; Li, Chenghui3,4; Wu, Qihuan5; Lu, Hongyang4,6 | |
2020-04-01 | |
发表期刊 | TRANSLATIONAL CANCER RESEARCH
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ISSN | 2218-676X |
通讯作者 | Lu, Hongyang(luhy@zjcc.org.cn) |
摘要 | Mutations in the epidermal growth factor receptor (EGFR) gene are the most common targetable genomic drivers of non-small cell lung cancer (NSCLC). 90% of the EGFR mutations comprise of EGFR exon 19 deletion and exon 21 L858R mutation, while EGFR exon 20 insertion (EGFR Ex20Ins) is the third most common type of EGFR mutation. Currently, studies on EGFR Ex20Ins are relatively scarce and limited. The frequency of EGFR Ex20Ins mutations in NSCLC was 1-10%. Patients harboring EGFR Ex20Ins exhibited similar clinical characteristics except for poorer prognosis as compared to patients with sensitizing mutations in EGFR. Conventional TKIs have poor efficacy in a majority of EGFR Ex20Ins subtypes. Chemotherapy remains the preferred treatment for advanced NSCLC patients harboring EGFR Ex20Ins. However, some novel inhibitors are considered as putative candidates. This review focuses on the structural and biochemical features, clinical characteristics, treatments, and prognosis of EGFR Ex20Ins in NSCLC. |
关键词 | EGFR exon 20 insertion mutations non-small cell lung cancer (NSCLC) EGFR-TKIs structural features clinical features treatment prognosis |
DOI | 10.21037/tcr.2020.03.10 |
关键词[WOS] | GROWTH-FACTOR-RECEPTOR ; NSCLC PATIENTS ; INHIBITOR ; EFFICACY ; HETEROGENEITY ; OSIMERTINIB ; AFATINIB ; OUTCOMES ; GENE ; RARE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Zhejiang Province Medical Science Fund[2019ZH019] ; CSCO-Qilu Cancer Research Foundation[Y-Q201802-008] ; 1022 Talent Training Program of Zhejiang Cancer Hospital |
项目资助者 | Zhejiang Province Medical Science Fund ; CSCO-Qilu Cancer Research Foundation ; 1022 Talent Training Program of Zhejiang Cancer Hospital |
WOS研究方向 | Oncology |
WOS类目 | Oncology |
WOS记录号 | WOS:000530914200083 |
出版者 | AME PUBL CO |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/103240 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Lu, Hongyang |
作者单位 | 1.Xiangshan First Peoples Hosp, Dept Med Oncol, Xiangshan 315700, Peoples R China 2.Wenzhou Med Univ, Grad Sch, Wenzhou 325035, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Peoples R China 4.Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Dept Thorac Med Oncol,Inst Canc Res & Basic Med S, Hangzhou 310022, Peoples R China 5.Xiangshan First Peoples Hosp, Dept Med Emergency, Xiangshan 315700, Peoples R China 6.Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci,Inst Canc Res & B, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou 310022, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Fenfang,Li, Chenghui,Wu, Qihuan,et al. EGFR exon 20 insertion mutations in non-small cell lung cancer[J]. TRANSLATIONAL CANCER RESEARCH,2020,9. |
APA | Wang, Fenfang,Li, Chenghui,Wu, Qihuan,&Lu, Hongyang.(2020).EGFR exon 20 insertion mutations in non-small cell lung cancer.TRANSLATIONAL CANCER RESEARCH,9. |
MLA | Wang, Fenfang,et al."EGFR exon 20 insertion mutations in non-small cell lung cancer".TRANSLATIONAL CANCER RESEARCH 9(2020). |
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