Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry

doi:10.1007/s00216-020-02602-y

HFCAS OpenIR

	Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry
	Zhou, Wenzhao 1,2; Huang, Chaoqun1 ; Zou, Xue1 ; Lu, Yan1 ; Xia, Lei1 ; Shen, Chengyin1 ; Chu, Yannan1
	2020-06-01
发表期刊	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN	1618-2642
通讯作者	Huang, Chaoqun(cqhuang@aiofm.ac.cn)
摘要	Breath analysis is a promising method for metabolomics studies and clinical diagnosis, as it enables the observation of metabolites in a convenient and noninvasive way. In this work, an atmospheric pressure photoionization (APPI) source was modified for online analysis of exhaled breath by coupling with quadrupole time-of-flight mass spectrometry (QTOFMS). Three parameters, namely, the capillary voltage, the sampling flow and the curtain gas flow of the APPI source, were optimized. Five healthy volunteers, three males and two females, were enrolled to test the performance of modified APPI-QTOFMS by analyzing their exhaled breath. A total of 21 compounds were tentatively identified, and four metabolites, namely, dimethyl selenoxide, delta-valerolactam, hydroxymandelic acid and palmitic amide were detected in the exhaled breath for the first time. The result shows that modified APPI-QTOFMS can be used for the online study of exhaled breath.
关键词	Breath analysis Modified APPI QTOFMS
DOI	10.1007/s00216-020-02602-y
关键词[WOS]	VOLATILE ORGANIC-COMPOUNDS ; ELECTROSPRAY-IONIZATION ; HUMAN SALIVA ; PTR-MS ; AIR ; ACETONE ; OXIDATION ; MICROEXTRACTION ; QUANTIFICATION ; CONDENSATE
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[61671434] ; National Natural Science Foundation of China[21876176] ; Key Program of 13th Five-Year Plan CASHIPS[KP-2017-25]
项目资助者	National Natural Science Foundation of China ; Key Program of 13th Five-Year Plan CASHIPS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS记录号	WOS:000528432100001
出版者	SPRINGER HEIDELBERG
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/103374
专题	中国科学院合肥物质科学研究院
通讯作者	Huang, Chaoqun
作者单位	1.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China 2.Zhejiang Inst Metrol, 300 Xiasha Rd, Hangzhou 310018, Zhejiang, Peoples R China
第一作者单位	医学物理与技术中心
通讯作者单位	医学物理与技术中心
推荐引用方式 GB/T 7714	Zhou, Wenzhao,Huang, Chaoqun,Zou, Xue,et al. Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2020,412.
APA	Zhou, Wenzhao.,Huang, Chaoqun.,Zou, Xue.,Lu, Yan.,Xia, Lei.,...&Chu, Yannan.(2020).Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,412.
MLA	Zhou, Wenzhao,et al."Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 412(2020).