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Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study | |
Zhou, Ling1,2,3,4; Chen, Jia5; Shen, Wei5; Chen, Zheng-Lu4; Huang, Shuang1,2,3; Tao, Chang-Juan1,2,3; Chen, Ming1,2,3; Yu, Zhong-Hua6; Chen, Yuan-Yuan1,2,3 | |
2020-03-23 | |
发表期刊 | RADIATION ONCOLOGY |
通讯作者 | Yu, Zhong-Hua(zhonghua_yu@126.com) ; Chen, Yuan-Yuan(chenyy@zjcc.org.cn) |
摘要 | Background We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and to guide individualized treatment. Methods A total of 206 patients with histologically proven nasopharyngeal carcinoma (NPC) treated at the Cancer Hospital of the University of Chinese Academy of Sciences between January 2015 and August 2018 were included. Dose-volume histogram (DVH) data, including mean dose, absolute volume, V-20, V-25, V-30, V-35, V-40, V-45, V-50,V- V-55, and V-60 were extracted and used as dosimetric parameters. A logistic regression analysis model was built to identify predictors related to HT occurring within 2 years. Results Sex, N stage, thyroid volume, mean thyroid dose, and thyroid V-20 and V-50 were significantly different between patients with and without HT. Logistic regression analysis showed that N stage, thyroid volume, and thyroid V-50 were independent predictors of HT. The radiosensitivity of the thyroid decreased as the thyroid volume increased. Patients with N stage > 1 had significantly higher HT incidence (37.38%) than patients with N stage <= 1 (13.11%). The incidence of HT was 54.55% in patients with thyroid V-50 > 24% and was 34.15% in patients with thyroid V-50 <= 24%. Conclusions The incidence of HT is significantly associated with N stage, thyroid volume, and thyroid V-50. More attention should be paid to patients with NPC with thyroid volume <= 12.82 cm(3) and advanced N stage disease. |
关键词 | Nasopharyngeal carcinoma Hypothyroidism Radiation therapy |
DOI | 10.1186/s13014-020-01490-x |
关键词[WOS] | QUALITY-OF-LIFE ; NECK-CANCER-PATIENTS ; RADIOTHERAPY ; HEAD |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81672971] ; Key Technologies Research and Development Program[2017YFC0113201] |
项目资助者 | National Natural Science Foundation of China ; Key Technologies Research and Development Program |
WOS研究方向 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000522186500001 |
出版者 | BMC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/103602 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Yu, Zhong-Hua; Chen, Yuan-Yuan |
作者单位 | 1.Chinese Acad Sci, ICBM, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou, Peoples R China 3.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 4.Guangdong Med Univ, Postgrad Educ, Zhanjiang, Peoples R China 5.Hangzhou YITU Healthcare Technol Co Ltd, Hangzhou, Peoples R China 6.Guangdong Med Univ, Dept Oncol, Affiliated Hosp, Zhanjiang, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Ling,Chen, Jia,Shen, Wei,et al. Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study[J]. RADIATION ONCOLOGY,2020,15. |
APA | Zhou, Ling.,Chen, Jia.,Shen, Wei.,Chen, Zheng-Lu.,Huang, Shuang.,...&Chen, Yuan-Yuan.(2020).Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study.RADIATION ONCOLOGY,15. |
MLA | Zhou, Ling,et al."Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study".RADIATION ONCOLOGY 15(2020). |
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