The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis

doi:10.1016/j.oraloncology.2019.104559

HFCAS OpenIR

	The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis
	Shu, Zekai 1; Li, Peijing 2,3; Yu, Bingqi 4; Huang, Shuang 2,3; Chen, Yuanyuan 2,3
	2020-03-01
发表期刊	ORAL ONCOLOGY
ISSN	1368-8375
通讯作者	Chen, Yuanyuan(chenyy@zjcc.org.cn)
摘要	Oral mucositis (OM) is a common and troublesome adverse side effect of many cancer therapy modalities (chemotherapy, radiotherapy, and chemo-radiotherapy), which can cause pain, ulceration, dysphagia, malnutrition, even treatment interruption. Probiotics may be effective in preventing and treating of cancer therapy-induced OM. We performed a systematic review and meta-analysis of the effectiveness of probiotics in prevention and treatment of cancer therapy-induced OM. Four databases and one trial registry were searched as of the 12th of May 2019 to identify all eligible randomized controlled trials (RCT). Five studies involving 435 patients were included in this study. Methodological quality and outcomes were evaluated in every study included. Pooled results showed a moderate heterogeneity (P = 0.15, I-2 = 44%). The pooled RRs indicated that the use of probiotics decreased the risk of OM for grade >= 3 (RR = 0.66, 95%CI = 0.54-0.81, P < 0.0001) as well as all grades (RR = 0.83, 95% CI = 0.72-0.97, P = 0.02). There was no significant difference between probiotics and placebo for cancer therapy completion rate (RR = 1.14, 95%CI = 0.65-2.00, P = 0.64). The subgroup analysis indicated that the use of probiotics was not statistically significant for patients receiving chemo-radiotherapy (RR = 0.52, 95% CI = 0.26-1.04, P = 0.07). In conclusion, probiotics may reduce the incidence and mitigate the severity of cancer therapy-induced OM. Further trials with a randomized, double-blind and multicentric study design are needed to confirm this effect. The PROSPERO registration number of this systematic review and meta-analysis is CRD42019130414.
关键词	Probiotics Radiotherapy Chemotherapy Chemo-radiotherapy Oral mucositis Stomatitis Head and neck cancer
DOI	10.1016/j.oraloncology.2019.104559
关键词[WOS]	LACTOBACILLUS-BREVIS CD2 ; DOUBLE-BLIND ; NECK-CANCER ; RADIATION ; HEAD ; SAFETY ; RISK ; CHEMOTHERAPY ; MICROBIOME ; MANAGEMENT
收录类别	SCI
语种	英语
WOS研究方向	Oncology ; Dentistry, Oral Surgery & Medicine
WOS类目	Oncology ; Dentistry, Oral Surgery & Medicine
WOS记录号	WOS:000518642200027
出版者	ELSEVIER
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/103770
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Yuanyuan
作者单位	1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Beijing, Peoples R China 4.Zhejiang Hosp, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Shu, Zekai,Li, Peijing,Yu, Bingqi,et al. The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis[J]. ORAL ONCOLOGY,2020,102.
APA	Shu, Zekai,Li, Peijing,Yu, Bingqi,Huang, Shuang,&Chen, Yuanyuan.(2020).The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis.ORAL ONCOLOGY,102.
MLA	Shu, Zekai,et al."The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis".ORAL ONCOLOGY 102(2020).