A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery

doi:10.1039/d0nr04751a

HFCAS OpenIR

	A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery
	Jiang, Kai 1; Chen, Yunsheng 2; Zhao, Di 1; Cheng, Jin 1; Mo, Fangli 1; Ji, Bin 1; Gao, Chao 1; Zhang, Chuan 3; Song, Jie 1,4,5
	2020-09-28
发表期刊	NANOSCALE
ISSN	2040-3364
通讯作者	Song, Jie(J.S.sjie@sjtu.edu.cn)
摘要	The transdermal drug delivery approach has been considered a potential therapy for human hypertrophic scars (HSs) instead of current uncomfortable surgical excision, local injection and laser therapy. However, a facile and efficient drug delivery method is urgently needed to overcome the skin barrier of transdermal administration. Herein, we employed a DNA-Fe nanoparticle delivery systemviaFe ion driven self-assembly to satisfy the requirement of transdermal administration for HS therapy. Doxorubicin hydrochloride (DOX) as one of the widely used anticancer drugs was employed to treat the hyperplasia of abnormal skin fibrous tissue. Bothin vitroandin vivoexperiments of the DOX loaded DNA-Fe nanoparticles (DOX@DNA-Fe NPs) were performed to demonstrate the penetration ability, rapid drug release, and scar-inhibiting effects. This facile and efficient approach for HS therapyviaa DNA-based transdermal drug delivery system may provide more possibilities for the development of transdermal administration.
DOI	10.1039/d0nr04751a
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; National Key Research and Development Program of China[2017YFC1200904] ; Medical Engineering Cross Project of Shanghai Jiaotong University[YG2017ZD07]
项目资助者	National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; National Key Research and Development Program of China ; Medical Engineering Cross Project of Shanghai Jiaotong University
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000572677500013
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/104212
专题	中国科学院合肥物质科学研究院
通讯作者	Song, Jie
作者单位	1.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Inst Nano Biomed & Engn, Dept Instrument Sci & Engn, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Frontiers Sci Ctr Ransformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Peoples R China 5.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Kai,Chen, Yunsheng,Zhao, Di,et al. A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery[J]. NANOSCALE,2020,12.
APA	Jiang, Kai.,Chen, Yunsheng.,Zhao, Di.,Cheng, Jin.,Mo, Fangli.,...&Song, Jie.(2020).A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery.NANOSCALE,12.
MLA	Jiang, Kai,et al."A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery".NANOSCALE 12(2020).