2019-nCoV may create complications in colon cancer patients with ACE2 expression

HFCAS OpenIR

	2019-nCoV may create complications in colon cancer patients with ACE2 expression
	Chen, Yongyi 1,2,3; Gong, Wangang 1,2,3; Wei, Haibin 1,2,3; Dai, Wumin 1,2,3; Xu, Songxiao 1,2,3
	2020
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
ISSN	1936-2625
通讯作者	Xu, Songxiao(xusx@zjcc.org.cn)
摘要	Since December 2019, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans. Much remains unknown about 2019-nCoV, especially the additional risks that 2019-nCoV infection may pose for colon cancer patients. Many reports show that angiotensin converting enzyme II (ACE2) is the cell receptor through which 2019-nCoV enters host cells, and this is similar to the cell entry mechanism of SARS coronavirus. Previous studies show that ACE2 is highly expressed in the gastrointestinal tract, especially in the colon. In patients with colon cancer, ACE2 expression is significantly increased in tumor tissues compared to tissues from patients with other types of cancer. One of the known regulators of endocytosis is the serine protease (TMPRSS2) and AP2-associated protein kinase 1 (AAK1), which also facilitates the passage of viruses into cells. Furthermore, the Database of Gene expression profiling interactive analysis suggests that expression levels for ACE2, TMPRSS2, and AAK1 are positively correlated in colon cells. Therefore, our findings predict that 2019-nCoV will create increased complications for patients with colon cancer.
关键词	2019-nCoV colon cancer ACE2 bioinformatics
收录类别	SCI
语种	英语
WOS研究方向	Oncology ; Pathology
WOS类目	Oncology ; Pathology
WOS记录号	WOS:000576775000010
出版者	E-CENTURY PUBLISHING CORP
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/104450
专题	中国科学院合肥物质科学研究院
通讯作者	Xu, Songxiao
作者单位	1.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Clin Lab, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Clin Lab, 1 East Banshan Rd, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yongyi,Gong, Wangang,Wei, Haibin,et al. 2019-nCoV may create complications in colon cancer patients with ACE2 expression[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2020,13.
APA	Chen, Yongyi,Gong, Wangang,Wei, Haibin,Dai, Wumin,&Xu, Songxiao.(2020).2019-nCoV may create complications in colon cancer patients with ACE2 expression.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,13.
MLA	Chen, Yongyi,et al."2019-nCoV may create complications in colon cancer patients with ACE2 expression".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 13(2020).