Correlation Between Hemoglobin Levels and the Prognosis of First-Line Chemotherapy in Patients with Advanced Gastric Cancer

doi:10.2147/CMAR.S256074

HFCAS OpenIR

	Correlation Between Hemoglobin Levels and the Prognosis of First-Line Chemotherapy in Patients with Advanced Gastric Cancer
	Wei, Qing 1,2; Yuan, Xing 1,2; Xu, Qi 1,2; Li, Jingjing 1,2; Chen, Lei 1,2; Ying, Jieer 1,2
	2020
发表期刊	CANCER MANAGEMENT AND RESEARCH
ISSN	1179-1322
通讯作者	Ying, Jieer(jieerying@aliyun.com)
摘要	Background: This retrospective study evaluated the prognostic significance of hemoglobin (Hb) levels in patients (pts) with unresectable locally advanced or metastatic gastric cancer who have not previously received chemotherapy. Patients and Methods: We screened 249 pts with advanced gastric cancer, who were categorized into four groups, namely, non-anemia (normal Hb levels), mild (10 g/dl to normal), moderate (8-10 g/dl), and severe anemia groups (<8 g/dl), to study the prognostic significance of Hb levels. We also examined the correlation between changes in Hb levels and treatment effects via imaging during the treatment course. Results: The objective response rate (ORR) was 47.4% for pts with anemia versus 43.4% for pts without anemia (P=0.536). Hemoglobin levels were reduced by 0.51 +/- 1.86 and 1.93 +/- 1.33 g/dl after chemotherapy versus before chemotherapy in the disease control group and progressive groups, respectively (P=0.002). The median progression-free survival (mPFS) of first-line chemotherapy in all pts was 6.3 months. Specifically, the mPFS was 5.7 months in pts with severe anemia, compared with 6.4 months for pts with non-severe anemia (Hb>8g/dl). The median overall survival (mOS) of all pts was 14.0 months. In particular, the mOS was 15.0 months for pts with non-anemia and mild anemia (Hb>10g/dl) versus 11.5 months for pts with moderate or severe anemia. In multivariate analysis, ascites and decreased Hb post-chemotherapy were identified as independent prognostic indicators for PFS and OS. Conclusion: Our findings indicate that Hb levels are associated with the prognosis in the first-line chemotherapy for pts with advanced gastric cancer. Pts with progressive disease experience a larger decrease in Hb levels, and those with baseline Hb levels >10 g/dl experience longer OS.
关键词	anemic hemoglobin gastric cancer prognosis
DOI	10.2147/CMAR.S256074
关键词[WOS]	EPOETIN-ALPHA ; ANEMIA ; OUTCOMES ; HYPOXIA ; OXALIPLATIN ; PREVALENCE ; GUIDELINES ; MANAGEMENT ; IMPACT ; TUMORS
收录类别	SCI
语种	英语
资助项目	Zhejiang Science Technology Plan Project[2017C37138]
项目资助者	Zhejiang Science Technology Plan Project
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000577372000006
出版者	DOVE MEDICAL PRESS LTD
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/104555
专题	中国科学院合肥物质科学研究院
通讯作者	Ying, Jieer
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Wei, Qing,Yuan, Xing,Xu, Qi,et al. Correlation Between Hemoglobin Levels and the Prognosis of First-Line Chemotherapy in Patients with Advanced Gastric Cancer[J]. CANCER MANAGEMENT AND RESEARCH,2020,12.
APA	Wei, Qing,Yuan, Xing,Xu, Qi,Li, Jingjing,Chen, Lei,&Ying, Jieer.(2020).Correlation Between Hemoglobin Levels and the Prognosis of First-Line Chemotherapy in Patients with Advanced Gastric Cancer.CANCER MANAGEMENT AND RESEARCH,12.
MLA	Wei, Qing,et al."Correlation Between Hemoglobin Levels and the Prognosis of First-Line Chemotherapy in Patients with Advanced Gastric Cancer".CANCER MANAGEMENT AND RESEARCH 12(2020).