Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery

doi:10.1016/j.cclet.2020.04.015

HFCAS OpenIR

	Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery
	Li, Ying 1; Cao, Xiuxiu 2; Tian, Changlin 1,2; Zheng, Ji-Shen 1
	2020-09-01
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
通讯作者	Zheng, Ji-Shen(jszheng@ustc.edu.cn)
摘要	D-peptides are recognized as a new class of synthetic chemical drugs and they possess many interesting advantages such as high enzymatic stability, improved oral bioavailability, as well as high binding affinity and specificity. Recently, D-peptide drugs have been attracting increasing attention in both academic and industrial researches over recent years. One D-peptide etelcalcetide has even entered the market that targets the calcium (Ca2+)-sensing receptor (CaSR) to fight secondary hyperparathyroidism. Effective discovery and optimization of D-peptide ligands that can bind to various disease-related targets with high specificity and potency is of great importance for the development of D-peptide drugs. This review surveys the recent method development in this area especially the chemical protein synthesis-assisted high-throughput screening strategies for D-peptide ligands and their application in drug discovery. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
关键词	Chemical protein synthesis Mirror-image proteins Mirror-image phage display Mirror-image one-bead one-compound (OBOC) D-Peptide drug
DOI	10.1016/j.cclet.2020.04.015
关键词[WOS]	IMAGE PHAGE DISPLAY ; BRAIN-BARRIER PENETRATION ; X-RAY STRUCTURES ; MIRROR-IMAGE ; PHARMACOKINETIC PROPERTIES ; MEMBRANE-PROTEINS ; UBIQUITIN CHAINS ; COILED-COIL ; HIV-1 ENTRY ; INHIBITORS
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2019YFA0706902] ; National Natural Science Foundation of China[U1732161] ; National Natural Science Foundation of China[91753120] ; Science and Technological Fund of Anhui Province for Outstanding Youth[1808085J04]
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technological Fund of Anhui Province for Outstanding Youth
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000582384200037
出版者	ELSEVIER SCIENCE INC
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/104827
专题	中国科学院合肥物质科学研究院
通讯作者	Zheng, Ji-Shen
作者单位	1.Univ Sci & Technol China, Sch Life Sci, Dept Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China 2.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Li, Ying,Cao, Xiuxiu,Tian, Changlin,et al. Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery[J]. CHINESE CHEMICAL LETTERS,2020,31.
APA	Li, Ying,Cao, Xiuxiu,Tian, Changlin,&Zheng, Ji-Shen.(2020).Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery.CHINESE CHEMICAL LETTERS,31.
MLA	Li, Ying,et al."Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery".CHINESE CHEMICAL LETTERS 31(2020).