The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy

doi:10.21037/tcr-20-796

HFCAS OpenIR

	The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy
	Fu, Zhiqin 1; Wang, Conghui 2; Chen, Jianhong 1; Wang, Yingchang 1; Zhang, Xiang 1
	2020-10-01
发表期刊	TRANSLATIONAL CANCER RESEARCH
ISSN	2218-676X
通讯作者	Zhang, Xiang(zhangxiang@zjcc.org.cn)
摘要	Background: This study aimed to investigate the incidence of and potential risk factors for acute radiation-induced dermatitis (RID) in patients with gynaecological malignancies who underwent intensity-modulated radiation therapy (IMRT). Methods: Ninety-six patients, who were diagnosed with gynaecological malignancies and underwent IMRT in the lower vagina and/or groin at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China) between January 2012 and June 2014, were enrolled. Clinical data were retrospectively collected. Acute RID grade >= 2 severity was defined as clinically relevant acute RID and sub-grouped accordingly. Univariate and multivariate analyses were performed. Results: The incidence of grades 0, 1, 2, 3, and 4 acute RID was 2.1%, 43.8%, 35.4%, 18.8%, and 0%, respectively. Univariate analysis revealed that clinically relevant acute RID was independently correlated with hyperglycaemia (defined as venous fasting blood glucose level >= 7.1 mmol/L for 2 consecutive measurements), concurrent chemotherapy, and prophylactic use of triethanolamine emulsion (P<0.05). Patient age (P=0.521), body mass index (BMI) (P=0.893), and radiation boost (P=0.870) were not statistically significant factors. All variables with P<0.1 were included in the multivariate analysis together with radiation boost. Similarly, clinically relevant acute RID was independently correlated with hyperglycaemia [odds ratio (OR) 3.150; 95% confidence interval (CI), 1.019-9.736; P=0.046], synchronous chemotherapy (OR 3.515; 95% CI, 1.362-9.072; P=0.009), and prophylactic use of triethanolamine emulsion (OR 0.412; 95% CI, 0.170-0.998; P=0.049). Conclusions: Hyperglycaemia and synchronous chemotherapy were independent predictive factors for clinically relevant acute RID. Prophylactic use of triethanolamine emulsion may help to reduce the incidence of clinically relevant acute RID.
关键词	Gynaecological malignancies intensity-modulated radiation therapy (IMRT) radiation-induced dermatitis (RID) triethanolamine
DOI	10.21037/tcr-20-796
关键词[WOS]	ADVANCED CERVICAL-CANCER ; RADIOTHERAPY ; TOXICITY ; CHEMORADIOTHERAPY ; CHEMOTHERAPY ; DISEASE ; HEAD ; NECK
收录类别	SCI
语种	英语
资助项目	Zhejiang Provincial Natural Science Foundation of China[LQ20H160006] ; Zhejiang Provincial Natural Science Foundation of China[LYY19H310001] ; Science and Technology Program of Zhejiang Chinese Traditional Medicine[2015ZB018] ; Science and Technology Program of Zhejiang Chinese Traditional Medicine[2017ZB021] ; Zhejiang Medical and Health Science and Technology Project[2017KY253] ; Zhejiang Medical and Health Science and Technology Project[2020KY059]
项目资助者	Zhejiang Provincial Natural Science Foundation of China ; Science and Technology Program of Zhejiang Chinese Traditional Medicine ; Zhejiang Medical and Health Science and Technology Project
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000585306900022
出版者	AME PUBL CO
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/105109
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xiang
作者单位	1.Chinese Acad Sci, Zhejiang Canc Hosp, Inst Canc Res & Basic Med Sci, Dept Gynecol Oncol,Canc Hosp,Univ Chinese Acad Sc, Hangzhou, Peoples R China 2.Zhejiang Univ, Womens Hosp, Sch Med, Womens Reprod Hlth Lab Zhejiang Prov, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Fu, Zhiqin,Wang, Conghui,Chen, Jianhong,et al. The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy[J]. TRANSLATIONAL CANCER RESEARCH,2020,9.
APA	Fu, Zhiqin,Wang, Conghui,Chen, Jianhong,Wang, Yingchang,&Zhang, Xiang.(2020).The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy.TRANSLATIONAL CANCER RESEARCH,9.
MLA	Fu, Zhiqin,et al."The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy".TRANSLATIONAL CANCER RESEARCH 9(2020).