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The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy | |
Fu, Zhiqin1; Wang, Conghui2; Chen, Jianhong1; Wang, Yingchang1; Zhang, Xiang1 | |
2020-10-01 | |
发表期刊 | TRANSLATIONAL CANCER RESEARCH |
ISSN | 2218-676X |
通讯作者 | Zhang, Xiang(zhangxiang@zjcc.org.cn) |
摘要 | Background: This study aimed to investigate the incidence of and potential risk factors for acute radiation-induced dermatitis (RID) in patients with gynaecological malignancies who underwent intensity-modulated radiation therapy (IMRT). Methods: Ninety-six patients, who were diagnosed with gynaecological malignancies and underwent IMRT in the lower vagina and/or groin at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China) between January 2012 and June 2014, were enrolled. Clinical data were retrospectively collected. Acute RID grade >= 2 severity was defined as clinically relevant acute RID and sub-grouped accordingly. Univariate and multivariate analyses were performed. Results: The incidence of grades 0, 1, 2, 3, and 4 acute RID was 2.1%, 43.8%, 35.4%, 18.8%, and 0%, respectively. Univariate analysis revealed that clinically relevant acute RID was independently correlated with hyperglycaemia (defined as venous fasting blood glucose level >= 7.1 mmol/L for 2 consecutive measurements), concurrent chemotherapy, and prophylactic use of triethanolamine emulsion (P<0.05). Patient age (P=0.521), body mass index (BMI) (P=0.893), and radiation boost (P=0.870) were not statistically significant factors. All variables with P<0.1 were included in the multivariate analysis together with radiation boost. Similarly, clinically relevant acute RID was independently correlated with hyperglycaemia [odds ratio (OR) 3.150; 95% confidence interval (CI), 1.019-9.736; P=0.046], synchronous chemotherapy (OR 3.515; 95% CI, 1.362-9.072; P=0.009), and prophylactic use of triethanolamine emulsion (OR 0.412; 95% CI, 0.170-0.998; P=0.049). Conclusions: Hyperglycaemia and synchronous chemotherapy were independent predictive factors for clinically relevant acute RID. Prophylactic use of triethanolamine emulsion may help to reduce the incidence of clinically relevant acute RID. |
关键词 | Gynaecological malignancies intensity-modulated radiation therapy (IMRT) radiation-induced dermatitis (RID) triethanolamine |
DOI | 10.21037/tcr-20-796 |
关键词[WOS] | ADVANCED CERVICAL-CANCER ; RADIOTHERAPY ; TOXICITY ; CHEMORADIOTHERAPY ; CHEMOTHERAPY ; DISEASE ; HEAD ; NECK |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Zhejiang Provincial Natural Science Foundation of China[LQ20H160006] ; Zhejiang Provincial Natural Science Foundation of China[LYY19H310001] ; Science and Technology Program of Zhejiang Chinese Traditional Medicine[2015ZB018] ; Science and Technology Program of Zhejiang Chinese Traditional Medicine[2017ZB021] ; Zhejiang Medical and Health Science and Technology Project[2017KY253] ; Zhejiang Medical and Health Science and Technology Project[2020KY059] |
项目资助者 | Zhejiang Provincial Natural Science Foundation of China ; Science and Technology Program of Zhejiang Chinese Traditional Medicine ; Zhejiang Medical and Health Science and Technology Project |
WOS研究方向 | Oncology |
WOS类目 | Oncology |
WOS记录号 | WOS:000585306900022 |
出版者 | AME PUBL CO |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/105109 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Zhang, Xiang |
作者单位 | 1.Chinese Acad Sci, Zhejiang Canc Hosp, Inst Canc Res & Basic Med Sci, Dept Gynecol Oncol,Canc Hosp,Univ Chinese Acad Sc, Hangzhou, Peoples R China 2.Zhejiang Univ, Womens Hosp, Sch Med, Womens Reprod Hlth Lab Zhejiang Prov, Hangzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Fu, Zhiqin,Wang, Conghui,Chen, Jianhong,et al. The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy[J]. TRANSLATIONAL CANCER RESEARCH,2020,9. |
APA | Fu, Zhiqin,Wang, Conghui,Chen, Jianhong,Wang, Yingchang,&Zhang, Xiang.(2020).The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy.TRANSLATIONAL CANCER RESEARCH,9. |
MLA | Fu, Zhiqin,et al."The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity-modulated radiation therapy".TRANSLATIONAL CANCER RESEARCH 9(2020). |
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