Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values

doi:10.3390/molecules25215141

HFCAS OpenIR

	Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values
	Zhu, Weiwei 1,2; Chen, Xiangsong1,2 ; Yuan, Lixia1 ; Wu, Jinyong1 ; Yao, Jianming1
	2020-11-01
发表期刊	MOLECULES
通讯作者	Yuan, Lixia(lxyuan@ipp.ac.cn) ; Yao, Jianming(jmyao@ipp.ac.cn)
摘要	The objective of this study was to investigate the stability and degradation kinetics of N-acetylneuraminic acid (Neu5Ac). The pH of the solution strongly influenced the stability of Neu5Ac, which was more stable at neutral pH and low temperatures. Here, we provide detailed information on the degradation kinetics of Neu5Ac at different pH values (1.0, 2.0, 11.0 and 12.0) and temperatures (60, 70, 80 and 90 degrees C). The study of the degradation of Neu5Ac under strongly acidic conditions (pH 1.0-2.0) is highly pertinent for the hydrolysis of polysialic acid. The degradation kinetics of alkaline deacetylation were also studied. Neu5Ac was highly stable at pH 3.0-10.0, even at high temperature, but the addition of H2O2 greatly reduced its stability at pH 5.0, 7.0 and 9.0. Although Neu5Ac has a number of applications in products of everyday life, there are no reports of rigorous shelf-life studies. This research provides kinetic data that can be used to predict product shelf lives at different temperatures and pH values.
关键词	degradation kinetics pH dependence hydrogen peroxide shelf life N-acetylneuraminic acid
DOI	10.3390/molecules25215141
关键词[WOS]	SIALIC-ACID ; THERMAL-DEGRADATION ; AQUEOUS-SOLUTION ; ANTHOCYANINS ; NMR ; SULFORAPHANE ; STABILITY
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China Youth Science Foundation Project[21506235]
项目资助者	National Natural Science Foundation of China Youth Science Foundation Project
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000589213500001
出版者	MDPI
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/105134
专题	中国科学院合肥物质科学研究院
通讯作者	Yuan, Lixia; Yao, Jianming
作者单位	1.Chinese Acad Sci, Inst Plasma Phys, Hefei Inst Phys Sci, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China
第一作者单位	中科院等离子体物理研究所
通讯作者单位	中科院等离子体物理研究所
推荐引用方式 GB/T 7714	Zhu, Weiwei,Chen, Xiangsong,Yuan, Lixia,et al. Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values[J]. MOLECULES,2020,25.
APA	Zhu, Weiwei,Chen, Xiangsong,Yuan, Lixia,Wu, Jinyong,&Yao, Jianming.(2020).Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values.MOLECULES,25.
MLA	Zhu, Weiwei,et al."Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values".MOLECULES 25(2020).