Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy

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	Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy
其他题名	Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy
	Yu Yue; Wang Xiaolei; Xu Zhengang; Fan Chengcheng; Li Qing
	2013
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
摘要	Background Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the potential prognostic effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy in our institution.
其他摘要	Background Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the potential prognostic effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy in our institution. Methods We performed a retrospective study of 279 patients with HPSCC who underwent radiotherapy with or without chemotherapy followed by neck dissection between November 1965 and December 2008. Patients were divided into four groups according to quartiles based on LNR. Results The mean LNR was 10.4% (range 0–100%, median 4.3%). Males and advanced clinical N classification significantly increased the LNR (P=0.014 and P <0.001, respectively). Compared with those with LNR <0.14, LNR ≥0.14 was associated with reduced overall, disease-specific and disease-free survival (all at P <0.001). Multivariate analysis revealed that LNR is an independent predictor of prognosis. Conclusion Our results suggest that LNR is a strong predictor of HPSCC after chemoradiotherapy.
关键词	NECK DISSECTION ORAL-CAVITY CANCER RADIOTHERAPY SURVIVAL QUALITY hypopharyngeal neoplasms neck dissection survival analysis lymphatic metastasis lymph node ratio
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4973247
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/106386
专题	中国科学院合肥物质科学研究院
作者单位	中国科学院合肥物质科学研究院肿瘤医院
第一作者单位	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	Yu Yue,Wang Xiaolei,Xu Zhengang,et al. Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy[J]. CHINESE MEDICAL JOURNAL,2013,126.
APA	Yu Yue,Wang Xiaolei,Xu Zhengang,Fan Chengcheng,&Li Qing.(2013).Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy.CHINESE MEDICAL JOURNAL,126.
MLA	Yu Yue,et al."Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy".CHINESE MEDICAL JOURNAL 126(2013).