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Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy | |
其他题名 | Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy |
Yu Yue; Wang Xiaolei; Xu Zhengang; Fan Chengcheng; Li Qing | |
2013 | |
发表期刊 | CHINESE MEDICAL JOURNAL |
ISSN | 0366-6999 |
摘要 | Background Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the potential prognostic effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy in our institution. |
其他摘要 | Background Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the potential prognostic effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy in our institution. Methods We performed a retrospective study of 279 patients with HPSCC who underwent radiotherapy with or without chemotherapy followed by neck dissection between November 1965 and December 2008. Patients were divided into four groups according to quartiles based on LNR. Results The mean LNR was 10.4% (range 0–100%, median 4.3%). Males and advanced clinical N classification significantly increased the LNR (P=0.014 and P <0.001, respectively). Compared with those with LNR <0.14, LNR ≥0.14 was associated with reduced overall, disease-specific and disease-free survival (all at P <0.001). Multivariate analysis revealed that LNR is an independent predictor of prognosis. Conclusion Our results suggest that LNR is a strong predictor of HPSCC after chemoradiotherapy. |
关键词 | NECK DISSECTION ORAL-CAVITY CANCER RADIOTHERAPY SURVIVAL QUALITY hypopharyngeal neoplasms neck dissection survival analysis lymphatic metastasis lymph node ratio |
收录类别 | CSCD |
语种 | 英语 |
CSCD记录号 | CSCD:4973247 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/106386 |
专题 | 中国科学院合肥物质科学研究院 |
作者单位 | 中国科学院合肥物质科学研究院肿瘤医院 |
第一作者单位 | 中国科学院合肥物质科学研究院 |
推荐引用方式 GB/T 7714 | Yu Yue,Wang Xiaolei,Xu Zhengang,et al. Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy[J]. CHINESE MEDICAL JOURNAL,2013,126. |
APA | Yu Yue,Wang Xiaolei,Xu Zhengang,Fan Chengcheng,&Li Qing.(2013).Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy.CHINESE MEDICAL JOURNAL,126. |
MLA | Yu Yue,et al."Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy".CHINESE MEDICAL JOURNAL 126(2013). |
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