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Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress | |
Wen, Qing-Liang1,2,3; Yi, He-Qing1,2,3; Yang, Ke1,2,3![]() | |
2021-03-01 | |
发表期刊 | MOLECULAR AND CELLULAR ENDOCRINOLOGY
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ISSN | 0303-7207 |
通讯作者 | Ge, Ming-Hua(geminghua@hmc.edu.cn) ; Zhu, Xin(zhuxin@zjcc.org.cn) |
摘要 | In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) in vitro and investigate the relationship between PIM-1 and redox proteins (NOX4, SOD2, and GPX2) at the tissue and cellular levels. As a PIM-1 inhibitor, SGI-1776 inhibited cell proliferation, colony formation, migration and induced an increase in apoptosis and reactive oxygen species in two PTC cell lines (BCPAP and TPC-1). The expressions of PIM-1, SOD2 and GPX2 were downregulated after siNOX4 exposure. Immunohistochemistry in 120 PTC patients showed that all four proteins exhibited higher expression levels in PTC tissues than in adjacent normal tissues. PIM-1 expression was related to NOX4, SOD2, and GPX2 expressions. The Cancer Genome Atlas database analysis showed the significant correlation between the expression of NOX4 and PIM-1. Our results demonstrated that PIM-1 played an important oncogenic role in PTC carcinogenesis that may be related to oxidative stress. |
关键词 | Papillary thyroid carcinoma PIM-1 Oxidative stress NOX4 |
DOI | 10.1016/j.mce.2020.111144 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[82072950] ; Zhejiang Province Natural Science Foundation of China[LY17H070003] ; Zhejiang Province Natural Science Foundation of China[LY20H180007] |
项目资助者 | National Natural Science Foundation of China ; Zhejiang Province Natural Science Foundation of China |
WOS研究方向 | Cell Biology ; Endocrinology & Metabolism |
WOS类目 | Cell Biology ; Endocrinology & Metabolism |
WOS记录号 | WOS:000614236500006 |
出版者 | ELSEVIER IRELAND LTD |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/119652 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Ge, Ming-Hua; Zhu, Xin |
作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 3.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China 4.Zhejiang Prov Peoples Hosp, Dept Head & Neck Surg, Hangzhou, Peoples R China 5.Zhejiang Chinese Med Univ, Stomatol Coll, Hangzhou, Peoples R China 6.Zhejiang Univ, Affiliated Jinhua Hosp, Sch Med, Jinhua, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Wen, Qing-Liang,Yi, He-Qing,Yang, Ke,et al. Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2021,523. |
APA | Wen, Qing-Liang.,Yi, He-Qing.,Yang, Ke.,Yin, Chang-Tian.,Yin, Wen-Juan.,...&Zhu, Xin.(2021).Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.MOLECULAR AND CELLULAR ENDOCRINOLOGY,523. |
MLA | Wen, Qing-Liang,et al."Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress".MOLECULAR AND CELLULAR ENDOCRINOLOGY 523(2021). |
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