High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks

doi:10.1016/j.bios.2020.112736

HFCAS OpenIR

	High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks
	Wang, Bingfang 1,2; Luo, Yuanyuan2,3 ; Gao, Lei 2,3; Liu, Bo1 ; Duan, Guotao 1
	2021
发表期刊	BIOSENSORS & BIOELECTRONICS
ISSN	0956-5663
通讯作者	Duan, Guotao(duangt@hust.edu.cn)
摘要	Accurate detection of glucose is essential for the diagnosis of diabetes, wherein effective and sensitive biosensors for glucose detection are needed. Here, we fabricated a glucose sensor based on field-effect transistor (FET) with bimetallic nickel-copper metal-organic frameworks (Ni/Cu-MOFs) as its channel layers which were grown in-situ through a simple one-step hydrothermal method and modified with glucose oxidase (GOD) by using glutaraldehyde (GA) as linkers. Due to the synergistic effect of Ni ions and Cu ions in MOFs, the sensor (GOD-GA-Ni/CuMOFs-FET) showed good field effect performance and great responses to glucose through enzymatic reactions. It displayed a piecewise linear relationship in the wide range (1 mu M-20 mM), and provided high sensitivity (26.05 mu Acm(-2) mM(-1)) in the low concentration (1-100 mu M) and a low detection limit (0.51 mu M). The sensor also had these advantages of high specificity, excellent reproducibility, good short-term stability and fast response time. Especially, it is indicated that the Ni/Cu-MOFs-FETs with high performance have the potential to be available sensors, paving the way for the application of bimetallic MOFs in biosensing.
关键词	Bimetallic metal-organic framework Glucose detection Biosensor Field effect transistor In situ growth method
DOI	10.1016/j.bios.2020.112736
关键词[WOS]	SENSOR ; DEVICE
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2019YFB2006002] ; National Natural Science Foundation of China[11674320] ; Key Research Projects of the Frontier Science CAS[QYZDB-SSW-JSC017]
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Key Research Projects of the Frontier Science CAS
WOS研究方向	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS类目	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
WOS记录号	WOS:000603554800001
出版者	ELSEVIER ADVANCED TECHNOLOGY
引用统计	被引频次：71[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/119960
专题	中国科学院合肥物质科学研究院
通讯作者	Duan, Guotao
作者单位	1.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Sch Opt & Elect Informat, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Wang, Bingfang,Luo, Yuanyuan,Gao, Lei,et al. High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks[J]. BIOSENSORS & BIOELECTRONICS,2021,171.
APA	Wang, Bingfang,Luo, Yuanyuan,Gao, Lei,Liu, Bo,&Duan, Guotao.(2021).High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks.BIOSENSORS & BIOELECTRONICS,171.
MLA	Wang, Bingfang,et al."High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks".BIOSENSORS & BIOELECTRONICS 171(2021).