Knowledge Management System of Hefei Institute of Physical Science，CAS
| In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents | |
Xu, Shuai1,2; Wang, Jiarong1 ; Wei, Yuan3; Zhao, Hongxin1; Tao, Tongxiang1,2; Wang, Hui1; Wang, Zhen1,2; Du, Juan3; Wang, Hongzhi4; Qian, Junchao4; Ma, Kun1; Wang, Junfeng1,2,5
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| 2020-12-23 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
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| ISSN | 1944-8244 |
| Corresponding Author | Qian, Junchao(qianjunchao@hmfl.ac.cn) ; Ma, Kun(makun@hmfl.ac.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn) |
| Abstract | Ultra-small-sized iron oxide nanoparticles with good biocompatibility are regarded as promising alternatives for the gadolinium-based contrast agents, which are widely used as a positive contrast agent in magnetic resonance imaging (MRI). However, the current preparation of the iron oxide magnetic nanoparticles with small sizes usually involves organic solvents, increasing the complexity of hydrophilic ligand replacement and reducing the synthesis efficiency. It remains a great challenge to explore new iron oxide nanoparticles with good biocompatibility and a high T-1 contrast effect. Here, we reported a cage-like protein architecture self-assembled by approximately 6-7 BSA (bovine serum albumin) subunits. The BSA nanocage was then used as a biotemplate to synthesize uniformed and monodispersed Fe2O3@BSA nanoparticles with ultra-small sizes (similar to 3.5 nm). The Fe2O3@BSA nanoparticle showed a high r(1) value of 6.8 mM(-1)s(-1) and a low r(2)/r(1) ratio of 10.6 at a 3 T magnetic field. Compared to Gd-DTPA, the brighter signal and prolonged angiographic effect of Fe2O3@BSA nanoparticles could greatly benefit steady-state and high-resolution imaging. The further in vivo and in vitro assessments of stability, toxicity, and renal clearance indicated a substantial potential as a T-1 contrast agent in preclinical MRI. |
| Keyword | BSA nanocage ultra-small iron oxide nanoparticles T-1 contrast agent magnetic resonance angiography biocompatibility renal clearance |
| DOI | 10.1021/acsami.0c13825 |
| WOS Keyword | IRON-OXIDE NANOPARTICLES ; INORGANIC NANOPARTICLES ; LIGAND-EXCHANGE ; FERRITIN ; PROTEIN ; FE3O4 ; IONS ; MRI ; NANOSTRUCTURES ; NANOCRYSTALS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[3190110313] ; National Natural Science Foundation of China[U1632274] ; National Natural Science Foundation of China[8197102295] ; National Natural Science Foundation of China[U1732157] ; Ministry of Science and Technology of China[2016YFA0400901] ; High Magnetic Field Laboratory of Anhui Province |
| Funding Organization | National Natural Science Foundation of China ; Ministry of Science and Technology of China ; High Magnetic Field Laboratory of Anhui Province |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS ID | WOS:000603397200004 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.hfcas.ac.cn:8080/handle/334002/120015 |
| Collection | 中国科学院合肥物质科学研究院 |
| Corresponding Author | Qian, Junchao; Ma, Kun; Wang, Junfeng |
| Affiliation | 1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230036, Peoples R China 3.Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Peoples R China 4.Chinese Acad Sci, Hefei Canc Hosp, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol,Hefei Inst Phys Sci, Hefei 230031, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Shuai,Wang, Jiarong,Wei, Yuan,et al. In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12. |
| APA | Xu, Shuai.,Wang, Jiarong.,Wei, Yuan.,Zhao, Hongxin.,Tao, Tongxiang.,...&Wang, Junfeng.(2020).In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents.ACS APPLIED MATERIALS & INTERFACES,12. |
| MLA | Xu, Shuai,et al."In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents".ACS APPLIED MATERIALS & INTERFACES 12(2020). |
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