XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma

doi:10.1097/MD.0000000000024150

HFCAS OpenIR

	XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma
	Zeng, Hui 1,2,3; Wang, Ying 4; Wang, Ying 1,2,3; Zhang, Yongjun 1,2,3
	2021-01-08
发表期刊	MEDICINE
ISSN	0025-7974
通讯作者	Zhang, Yongjun(zhangyj@zjcc.org.cn)
摘要	Background: There is evidence that DNA methylation play major roles in lung cancer. In our previously study, C3 or f21 , also referred to as XXYLT1, rs2131877 polymorphism is associated with a reduced risk of lung adenocarcinoma. So, we explored the role of XXYLT1 methylation in lung adenocarcinoma. Methods: This study was conducted in 2 steps. In the first step, we recruited 15 patients with lung adenocarcinoma. Cancer tissues and para-carcinoma tissues were obtained from each of the patients. In the second step, 150 patients with lung adenocarcinom were enrolled, and cancer and normal lung tissue were obtained from each patients, respectively. The expression levels of XXYLT1 mRNA were determined, the deoxyribonucleic acid methylation status was analyzed by MassARRAY Spectrometry. The methylation data of individual units were generated by EpiTyper v1.0.5 software. Results: The XXYLT1 mRNA expression was significantly lower in cancer tissues than in para-carcinoma and normal lung tissues. Meanwhile, the methylation rates of three CpG units (CpG_23, CpG_25, and CpG_60.61.62.63.64.65) within the XXYLT1 gene were higher in cancer tissues compared to the para-carcinoma and the normal lung tissues. This difference was particularly significant in male patients. Conclusions: Our results suggested that methylation of XXYLT1 may have significance in the pathogenesis of lung adenocarcinoma.
关键词	Lung adenocarcinoma DNA methylation gene expression XXYLT1
DOI	10.1097/MD.0000000000024150
收录类别	SCI
语种	英语
资助项目	Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2019KY043] ; Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2020KY470]
项目资助者	Zhejiang Provincial Medical and Health Scientific and Technical Foundation
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:000612794500071
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/120195
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Yongjun
作者单位	1.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Beijing, Peoples R China 3.Zhejiang Canc Hosp, Hangzhou, Peoples R China 4.Zhejiang Chinese Med Univ, Dept Basic Med Sci, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Hui,Wang, Ying,Wang, Ying,et al. XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma[J]. MEDICINE,2021,100.
APA	Zeng, Hui,Wang, Ying,Wang, Ying,&Zhang, Yongjun.(2021).XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma.MEDICINE,100.
MLA	Zeng, Hui,et al."XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma".MEDICINE 100(2021).