DNA hydrogel-based gene editing and drug delivery systems

doi:10.1016/j.addr.2020.07.018

HFCAS OpenIR

	DNA hydrogel-based gene editing and drug delivery systems
	Mo, Fangli 1; Jiang, Kai 1; Zhao, Di 1; Wang, Yuqi 1; Song, Jie 1,2; Tan, Weihong 2
	2021
发表期刊	ADVANCED DRUG DELIVERY REVIEWS
ISSN	0169-409X
通讯作者	Song, Jie(sjie@sjtu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
摘要	Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost arbitrary geometry in two and three dimensions. Among various DNA-based soft materials, DNA hydrogels are comprised of hydrophilic polymeric networks of crosslinked DNA chains. For their properties of biocompatibility, porosity, sequence programmability and tunable multifunctionality, DNA hydrogels have been widely studied in bioanalysis and biomedicine. In this review, recent developments in DNA hydrogels and their applications in drug delivery systems are highlighted. First, physical and chemical crosslinking methods for constructing DNA hydrogels are introduced. Subsequently, responses of DNA hydrogels to nonbiological and biological stimuli are described. Finally, DNA hydrogel-based delivery platforms for different types of drugs are detailed. With the emergence of gene therapy, this review also gives future prospects for combining DNA hydrogels with the gene editing toolbox. (c) 2020 Elsevier B.V. All rights reserved.
关键词	DNA hydrogels Stimuli responsiveness Drug delivery Biomacromolecules Gene therapy
DOI	10.1016/j.addr.2020.07.018
关键词[WOS]	APTAMER-FUNCTIONALIZED HYDROGEL ; CROSS-LINKED HYDROGEL ; ACUTE KIDNEY INJURY ; QUANTUM DOTS ; RNA INTERFERENCE ; BIOMEDICAL APPLICATIONS ; RESPONSIVE HYDROGELS ; EFFICIENT DELIVERY ; CO-DELIVERY ; IN-VITRO
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; National Natural Science Foundation of China[21605102] ; National Key Research and Development Program of China[2017YFC1200904] ; Natural Science Foundation of Shanghai[19520714100] ; Natural Science Foundation of Shanghai[19ZR1475800]
项目资助者	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shanghai
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000612867300005
出版者	ELSEVIER
引用统计	被引频次：135[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/120289
专题	中国科学院合肥物质科学研究院
通讯作者	Song, Jie; Tan, Weihong
作者单位	1.Shanghai Jiao Tong Univ, Inst Nano Biomed & Engn, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Shanghai 200240, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Mo, Fangli,Jiang, Kai,Zhao, Di,et al. DNA hydrogel-based gene editing and drug delivery systems[J]. ADVANCED DRUG DELIVERY REVIEWS,2021,168.
APA	Mo, Fangli,Jiang, Kai,Zhao, Di,Wang, Yuqi,Song, Jie,&Tan, Weihong.(2021).DNA hydrogel-based gene editing and drug delivery systems.ADVANCED DRUG DELIVERY REVIEWS,168.
MLA	Mo, Fangli,et al."DNA hydrogel-based gene editing and drug delivery systems".ADVANCED DRUG DELIVERY REVIEWS 168(2021).