miR-588 is a prognostic marker in gastric cancer

HFCAS OpenIR

	miR-588 is a prognostic marker in gastric cancer
	Chen, Yongyi 1,2,3; Zhang, Jie 4; Gong, Wangang 1,2,3; Dai, Wumin 1,2,3; Xu, Xiaohong 1,2,3; Xu, Songxiao 1,2,3
	2021-01-31
发表期刊	AGING-US
ISSN	1945-4589
通讯作者	Xu, Songxiao(xusx@zjcc.org.cn)
摘要	In an effort to identify a novel microRNA (miRNA) as a gastric cancer (GC) treatment target and prognostic biomarker, we surveyed The Cancer Genome Atlas database and found that miR-588 expression is low in GC tissues. This was confirmed by real-time reverse transcription polymerase chain reaction assays of GC patient plasma samples and SGC7901 and MNK28 cells. A constructed miRNA-mRNA network showed that CXCL5, CXCL9, and CXCL10 are target genes of miR-588. Analysis of the miRWalk database revealed that miR-588 directly binds to CXCL5 and CXCL9. Overexpression of miR-588 reduced GC cell proliferation in vitro and in vivo. High expression of miR-588 inhibited Ki-67 expression in vivo. The FunRich database also showed that CXCL5, CXCL9, and CXCL10 are involved in immune responses, while the Database of Immune Cell Expression showed they are differentially expressed in CD8+ T cells. High expression of CXCL9 and CXCL10 correlated positively with infiltrating levels of CD4+ T and CD8+ T cells in stomach adenocarcinoma. High expression of miR-588, CXCL5, CXCL9, and CXCL10 was associated with prolonged survival of GC patients. These findings indicate that miR-588 is a biomarker for tumor-associated immune infiltration and a prognostic marker in GC patients.
关键词	gastric cancer miR-588 immune infiltration bioinformatics analysis
关键词[WOS]	SELF-RENEWAL ; INVASION ; MICRORNA-588 ; MIGRATION ; SURVIVAL ; TARGET ; CXCL5
收录类别	SCI
语种	英语
资助项目	Zhejiang province public welfare technology application research project[2020362827]
项目资助者	Zhejiang province public welfare technology application research project
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
WOS类目	Cell Biology ; Geriatrics & Gerontology
WOS记录号	WOS:000614644400004
出版者	IMPACT JOURNALS LLC
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/120482
专题	中国科学院合肥物质科学研究院
通讯作者	Xu, Songxiao
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 3.Chinese Acad Sci, Hangzhou, Zhejiang, Peoples R China 4.Zhejiang Prov Ctr Drug & Med Device Procurement, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yongyi,Zhang, Jie,Gong, Wangang,et al. miR-588 is a prognostic marker in gastric cancer[J]. AGING-US,2021,13.
APA	Chen, Yongyi,Zhang, Jie,Gong, Wangang,Dai, Wumin,Xu, Xiaohong,&Xu, Songxiao.(2021).miR-588 is a prognostic marker in gastric cancer.AGING-US,13.
MLA	Chen, Yongyi,et al."miR-588 is a prognostic marker in gastric cancer".AGING-US 13(2021).