Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer

doi:10.21037/tcr-20-2744

HFCAS OpenIR

	Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer
	Gong, Wangang 1,2; Chen, Yongyi 1,2; Zhang, Yingli 1,2
	2021-02-01
发表期刊	TRANSLATIONAL CANCER RESEARCH
ISSN	2218-676X
通讯作者	Zhang, Yingli(zhangyl@zjcc.org.cn)
摘要	Background: Members of the solute carrier (SLC)7 family are known to play important roles in tumorigenesis and development. However, the prognostic significance of the SLC7 family in ovarian cancer (OC) remains unknown. Methods: Expression patterns of SLC7 family members in OC were analyzed using gene expression profiling interactive analysis (GEPIA). The Kaplan-Meier plotter was applied to evaluate associations of the SLC7 gene family with prognosis of OC. SLC7A1 expression was additionally analyzed via immunohistochemical staining. chi(2), Kaplan-Meier and Cox regression analysis were used to evaluate the relationship between SLC7A1 expression and clinicopathological features, platinum resistance and prognosis in patients with high-grade serous ovarian cancer (HGSOC). Results: The GEPIA dataset revealed the abundant expression of SLC7A1, SLC7A4, and SLC7A7, and conversely, the low expression of SLC7A2 and SLC7A8 in OC relative to normal tissue samples. Kaplan-Meier survival analysis further indicated that high SLC7A1 and low SLC7A2 mRNA levels were significantly associated with overall survival (P<0.05). Positive SLC7A1 expression was detected in 65 (58.1%) HGSOC tissue samples, but not in all normal ovarian tissue samples (100%), indicating that the expression of SLC7A1 in HGSOC tissues was significantly higher than that in normal ovarian tissues (P<0.001). Additionally, expression of SLC7A1 was negatively associated with relapse-free survival (RFS; P<0.05). Conclusions: SLC7A1 is a potential prognostic biomarker of OC.
关键词	Ovarian cancer (OC) SLC7A1 relapse-free survival
DOI	10.21037/tcr-20-2744
关键词[WOS]	SLC TRANSPORTERS ; EXPRESSION ; RESISTANCE
收录类别	SCI
语种	英语
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000624363300004
出版者	AME PUBL CO
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/120910
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Yingli
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Gong, Wangang,Chen, Yongyi,Zhang, Yingli. Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer[J]. TRANSLATIONAL CANCER RESEARCH,2021,10.
APA	Gong, Wangang,Chen, Yongyi,&Zhang, Yingli.(2021).Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer.TRANSLATIONAL CANCER RESEARCH,10.
MLA	Gong, Wangang,et al."Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer".TRANSLATIONAL CANCER RESEARCH 10(2021).