Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally

doi:10.1038/s41598-020-79569-4

HFCAS OpenIR

	Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally
	Chen, Wei 1; Geng, Jia 2; Tan, Ya-lan 3; Zhao, Lian 1; Jia, Hui-hui 1; Guo, Wan-liang 1
	2021-01-08
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
通讯作者	Guo, Wan-liang(gwlsuzhou@163.com)
摘要	The general condition, clinical and pathological characteristics, and treatment regimens of patients prenatally and postnatally diagnosed with congenital choledochal malformation (CM) were analyzed in order to investigate the clinical significance of early diagnosis, treatment, and intervention in CM. We retrospectively analyzed 33 children who were admitted to the Children's Hospital of Soochow University between 1 March 2010 and 31 May 2019, and their diagnosis of CM was confirmed by radiological, surgical and pathological findings. All the patients were under 36 months of age. The patients were divided into prenatally diagnosed and postnatally diagnosed groups. There were 16 and 17 CM patients in the prenatally and postnatally diagnosed groups, respectively, with a preponderance of females in both groups. Compared with the prenatally diagnosed group, the postnatally diagnosed group had a higher incidence of abdominal pain and vomiting (p<0.05) and higher AST, GGT, and TB levels (p<0.05). Although postoperative histopathological examination showed inflammation in both groups, congestion in the cyst walls and fibrous tissue hyperplasia were more significant in the postnatally diagnosed group (p<0.05). In addition, operation time, length of time required to resume a normal diet after surgery, and total length of hospitalization differed between the 2 groups (p<0.05), with the prenatally diagnosed group having a relatively longer operation time and taking longer to resume a normal diet after surgery. However, the total length of hospitalization in the prenatally diagnosed group was shorter than that in the postnatally diagnosed group. Compared with prenatally diagnosed CM patients, more symptoms, greater severity of symptoms, and more time to recovery after surgery were observed in postnatally diagnosed CM patients.
DOI	10.1038/s41598-020-79569-4
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation[81971685] ; Science and Technology Project of Suzhou[SS201868]
项目资助者	National Natural Science Foundation ; Science and Technology Project of Suzhou
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000634374700012
出版者	NATURE RESEARCH
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/121338
专题	中国科学院合肥物质科学研究院
通讯作者	Guo, Wan-liang
作者单位	1.Soochow Univ, Dept Radiol, Childrens Hosp, Suzhou 215025, Peoples R China 2.3rd Hosp Yulin City, Clin Lab, Yulin 719000, Peoples R China 3.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wei,Geng, Jia,Tan, Ya-lan,et al. Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally[J]. SCIENTIFIC REPORTS,2021,11.
APA	Chen, Wei,Geng, Jia,Tan, Ya-lan,Zhao, Lian,Jia, Hui-hui,&Guo, Wan-liang.(2021).Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally.SCIENTIFIC REPORTS,11.
MLA	Chen, Wei,et al."Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally".SCIENTIFIC REPORTS 11(2021).