Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals

doi:10.1088/1748-605X/abef54

HFCAS OpenIR

	Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals
	Miao,Yashuang 1; Chen,Peirong 1; Yan,Miao 2,3; Xiao,Jianmin 2,3; Hong,Biao 2,3; Zhou,Ke 4; Zhang,Guilong 5; Qian,Junchao4 ; Wu,Zhengyan2,3
	2021-04-02
发表期刊	Biomedical Materials
ISSN	1748-6041
通讯作者	Chen,Peirong() ; Qian,Junchao() ; Wu,Zhengyan()
摘要	AbstractSingle-mode magnetic resonance imaging (MRI) contrast agents (CAs) in clinical settings are easily disturbed by calcification, bleeding, and adipose signals, which result in inaccurate diagnoses. In this study, we developed a highly efficient T1–T2 dual-mode MRI CA using an ultra-small gadolinium oxide-decorated magnetic iron oxide nanocrystal (GMIO). The gadolinium element could effectively alter the magnetic properties of the GMIO from soft-ferromagnetism to superparamagnetism. In addition, when the Gd/Fe ratio was 15% (designated as GMIO-2), the GMIO-2 possessed the best superparamagnetism and highest magnetism. Subsequently, T1 and T2 values of GMIO-2 were measured through a series of turbo spin-echo images and then multi-spin echo sequence, respectively. Based on this, T1 and T2 relaxivities of GMIO-2 were calculated and were the highest (r1: 1.306 m M?1 s?1 and r2: 234.5 m M?1 s?1) when compared to other groups. The cytotoxicity of GMIO-2 was negligible under a wide range of dosages, thus exhibiting excellent cell biocompatibility. Moreover, GMIO-2 could quickly diffuse into cells, leading to its effective accumulation. The systemic delivery of GMIO-2 resulted in an excellent T1–T2 dual-mode MRI contrast effect in kidneys, which is expected to improve the diagnosis of kidney lesions. Therefore, this work provides a promising candidate for the development of a T1–T2 dual-mode MRI CA.
关键词	iron oxide nanocrystals gadolinium oxide-decorated superparamagnetism dual-mode magnetic resonance imaging
DOI	10.1088/1748-605X/abef54
语种	英语
WOS记录号	IOP:1748-6041-16-4-abef54
出版者	IOP Publishing
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/121882
专题	中国科学院合肥物质科学研究院
通讯作者	Chen,Peirong; Qian,Junchao; Wu,Zhengyan
作者单位	1.Department of Applied Chemistry, School of Science, Anhui Agricultural University, Hefei 230036, People’s Republic of China 2.Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China 3.University of Science and Technology of China, Hefei 230026, People’s Republic of China 4.Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China 5.School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People’s Republic of China
通讯作者单位	中科院强磁场科学中心
推荐引用方式 GB/T 7714	Miao,Yashuang,Chen,Peirong,Yan,Miao,等. Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals[J]. Biomedical Materials,2021,16.
APA	Miao,Yashuang.,Chen,Peirong.,Yan,Miao.,Xiao,Jianmin.,Hong,Biao.,...&Wu,Zhengyan.(2021).Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals.Biomedical Materials,16.
MLA	Miao,Yashuang,et al."Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals".Biomedical Materials 16(2021).