HFCAS OpenIR
Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals
Miao,Yashuang1; Chen,Peirong1; Yan,Miao2,3; Xiao,Jianmin2,3; Hong,Biao2,3; Zhou,Ke4; Zhang,Guilong5; Qian,Junchao4; Wu,Zhengyan2,3
2021-04-02
Source PublicationBiomedical Materials
ISSN1748-6041
Corresponding AuthorChen,Peirong() ; Qian,Junchao() ; Wu,Zhengyan()
AbstractAbstractSingle-mode magnetic resonance imaging (MRI) contrast agents (CAs) in clinical settings are easily disturbed by calcification, bleeding, and adipose signals, which result in inaccurate diagnoses. In this study, we developed a highly efficient T1–T2 dual-mode MRI CA using an ultra-small gadolinium oxide-decorated magnetic iron oxide nanocrystal (GMIO). The gadolinium element could effectively alter the magnetic properties of the GMIO from soft-ferromagnetism to superparamagnetism. In addition, when the Gd/Fe ratio was 15% (designated as GMIO-2), the GMIO-2 possessed the best superparamagnetism and highest magnetism. Subsequently, T1 and T2 values of GMIO-2 were measured through a series of turbo spin-echo images and then multi-spin echo sequence, respectively. Based on this, T1 and T2 relaxivities of GMIO-2 were calculated and were the highest (r1: 1.306 m M?1 s?1 and r2: 234.5 m M?1 s?1) when compared to other groups. The cytotoxicity of GMIO-2 was negligible under a wide range of dosages, thus exhibiting excellent cell biocompatibility. Moreover, GMIO-2 could quickly diffuse into cells, leading to its effective accumulation. The systemic delivery of GMIO-2 resulted in an excellent T1–T2 dual-mode MRI contrast effect in kidneys, which is expected to improve the diagnosis of kidney lesions. Therefore, this work provides a promising candidate for the development of a T1–T2 dual-mode MRI CA.
Keywordiron oxide nanocrystals gadolinium oxide-decorated superparamagnetism dual-mode magnetic resonance imaging
DOI10.1088/1748-605X/abef54
Language英语
WOS IDIOP:1748-6041-16-4-abef54
PublisherIOP Publishing
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/121882
Collection中国科学院合肥物质科学研究院
Corresponding AuthorChen,Peirong; Qian,Junchao; Wu,Zhengyan
Affiliation1.Department of Applied Chemistry, School of Science, Anhui Agricultural University, Hefei 230036, People’s Republic of China
2.Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China
3.University of Science and Technology of China, Hefei 230026, People’s Republic of China
4.Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China
5.School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People’s Republic of China
Corresponding Author AffilicationChinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Miao,Yashuang,Chen,Peirong,Yan,Miao,等. Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals[J]. Biomedical Materials,2021,16.
APA Miao,Yashuang.,Chen,Peirong.,Yan,Miao.,Xiao,Jianmin.,Hong,Biao.,...&Wu,Zhengyan.(2021).Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals.Biomedical Materials,16.
MLA Miao,Yashuang,et al."Highly sensitive T1–T2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals".Biomedical Materials 16(2021).
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