Liquid biopsies to distinguish malignant from benign pulmonary nodules

doi:10.1111/1759-7714.13982

HFCAS OpenIR

	Liquid biopsies to distinguish malignant from benign pulmonary nodules
	Tao, Rui 1; Cao, Wei 2; Zhu, Feng 3; Nie, Jinfu 4,5; Wang, Hongzhi4,5 ; Wang, Lixiang 2; Liu, Pengcheng 1; Chen, Hailong 1; Hong, Bo 4,5; Zhao, Dahai 1
	2021-05-07
发表期刊	THORACIC CANCER
ISSN	1759-7706
通讯作者	Hong, Bo(bhong@hmfl.ac.cn) ; Zhao, Dahai(zhaodahai@ahmu.edu.cn)
摘要	Over the past decades, low-dose computed tomography (LD-CT) screening has been widely used for the early detection of lung cancer. Increasing numbers of indeterminate pulmonary nodules are now being discovered. However, it remains challenging to distinguish malignant from benign pulmonary nodules, especially those considered to be small or ground-glass (GGN) nodules. Liquid biopsies have been successfully applied in the diagnosis of advanced lung cancer, and the potential value for early detection of lung cancer has made great progress. Recent studies have demonstrated the value of various blood-based tumor biomarkers in determining the nature of pulmonary nodules, including cell-free DNA (cfDNA), microRNAs (miRNAs), circulating tumor cells (CTCs) and tumor-associated autoantibodies (AAbs). In this review, we summarize the latest progress of liquid biopsies, and their potential applications and challenges in the diagnosis of malignant pulmonary nodules.
关键词	biomarker cell‐ free DNA liquid biopsy miRNA pulmonary nodule diagnosis
DOI	10.1111/1759-7714.13982
收录类别	SCI
语种	英语
资助项目	Key Research and Development Project of Anhui Province[201904a07020064] ; Second Affiliated Hospital of Anhui Medical University[LHJJ202002] ; Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences[LHJJ202002] ; National Natural Science Foundation of China[81872438] ; Hefei Innovation Project[J2018Y04] ; CAPTRA-Lung Research Funds[CAPTRALung2020004]
项目资助者	Key Research and Development Project of Anhui Province ; Second Affiliated Hospital of Anhui Medical University ; Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Hefei Innovation Project ; CAPTRA-Lung Research Funds
WOS研究方向	Oncology ; Respiratory System
WOS类目	Oncology ; Respiratory System
WOS记录号	WOS:000647855900001
出版者	WILEY
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/122005
专题	中国科学院合肥物质科学研究院
通讯作者	Hong, Bo; Zhao, Dahai
作者单位	1.Anhui Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, 678 Furong Rd, Hefei 230601, Peoples R China 2.Anhui Med Univ, Affiliated Hosp 2, Dept Cardiothorac Surg, Hefei, Peoples R China 3.Anhui Med Univ, Anhui Chest Hosp, Dept Thorac Surg, Thorac Clin Coll, Hefei, Peoples R China 4.Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Heath & Med Technol, Hefei Inst Phys Sci, 350 Shushanhu Rd, Hefei 230031, Peoples R China 5.Chinese Acad Sci, Hefei Canc Hosp, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Tao, Rui,Cao, Wei,Zhu, Feng,et al. Liquid biopsies to distinguish malignant from benign pulmonary nodules[J]. THORACIC CANCER,2021.
APA	Tao, Rui.,Cao, Wei.,Zhu, Feng.,Nie, Jinfu.,Wang, Hongzhi.,...&Zhao, Dahai.(2021).Liquid biopsies to distinguish malignant from benign pulmonary nodules.THORACIC CANCER.
MLA	Tao, Rui,et al."Liquid biopsies to distinguish malignant from benign pulmonary nodules".THORACIC CANCER (2021).