Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening

doi:10.1186/s12938-021-00889-1

HFCAS OpenIR

	Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening
	Ni,Jingshu 1,2; Hong,Haiou 4; Zhang,Yang1,2 ; Tang,Shiqi 5; Han,Yongsheng 6; Fang,Zhaohui 7; Zhang,Yuanzhi1,3 ; Zhou,Nan1,3 ; Wang,Quanfu 1,3; Liu,Yong1,2,3 ; Li,Zhongsheng 1; Wang,YiKun1,2 ; Dong,Meili1,2
	2021-06-01
发表期刊	BioMedical Engineering OnLine
通讯作者	Wang,YiKun(wyk@aiofm.ac.cn) ; Dong,Meili(dongmeili@aiofm.ac.cn)
摘要	AbstractBackgroundEstablishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an independent risk factor of early assessment of atherosclerotic risk.MethodsWe propose a non-invasive skin cholesterol detection method based on absorption spectroscopy. Detection reagents specifically bind to skin cholesterol and react with indicator to produce colored products, the skin cholesterol content can be obtained through absorption spectrum information on colored products detected by non-invasive technology. Gas chromatography is used to measure cholesterol extracted from the skin to verify the accuracy and reliability of the non-invasive test method. A total of 342 subjects were divided into normal group (n?=?115), disease group (n?=?110) and risk group (n?=?117). All subjects underwent non-invasive skin cholesterol test. The diagnostic accuracy of the measured value was analyzed by receiver-operating characteristic (ROC) curve.ResultsThe proposed method is able to identify porcine skin containing gradient concentration of cholesterol. The values measured by non-invasive detection method were significantly correlated with gas chromatography measured results (r?=?0.9074, n?=?73, p?
关键词	Non-invasive Skin cholesterol Absorption spectroscopy Subclinical atherosclerosis
DOI	10.1186/s12938-021-00889-1
关键词[WOS]	CARDIOVASCULAR RISK ; TISSUE CHOLESTEROL ; PRIMARY PREVENTION ; BARRIER FUNCTION ; STRATUM-CORNEUM ; DERMATITIS ; INFLAMMATION ; ABSORPTION ; DEPOSITION ; DIGITONIN
收录类别	SCI
语种	英语
资助项目	Science and Technology Major Project of Anhui Province of China[201903a07020027] ; Science and Technology Major Project of Anhui Province of China[17030801007] ; Science and Technology Major Project of Anhui Province of China[17030901017] ; Science and Technology Service Network Project, Chinese Academy of Sciences[KFJSTS-QYZD-184] ; Science and Technology Service Network Project, Chinese Academy of Sciences[KFF-STS-ZDTP-063] ; External Cooperation Program of the Bureau of International Cooperation, Chinese Academy of Sciences[116134KYSB20170018] ; Natural Science Foundation of Anhui Province of China[1908085QH365] ; Key research and Development Program of Anhui Province of China[1804b06020350] ; Key research and Development Program of Anhui Province of China[1804h08020291] ; Key research and Development Program of Anhui Province of China[202004a07020016]
项目资助者	Science and Technology Major Project of Anhui Province of China ; Science and Technology Service Network Project, Chinese Academy of Sciences ; External Cooperation Program of the Bureau of International Cooperation, Chinese Academy of Sciences ; Natural Science Foundation of Anhui Province of China ; Key research and Development Program of Anhui Province of China
WOS研究方向	Engineering
WOS类目	Engineering, Biomedical
WOS记录号	BMC:10.1186/s12938-021-00889-1
出版者	BioMed Central
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/122290
专题	中国科学院合肥物质科学研究院
通讯作者	Wang,YiKun; Dong,Meili
作者单位	1.Chinese Academy of Sciences; Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science 2.University of Science and Technology of China 3.Wanjiang Center for Development of Emerging Industrial Technology 4.First Affiliated Hospital of University of Science and Technology of China; Health Management Center 5.Renmin Hospital of WuHan University; Health Management Center 6.First Affiliated Hospital of University of Science and Technology of China; Department of Cardiovascular Medicine 7.The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine; Department of Endocrinology
推荐引用方式 GB/T 7714	Ni,Jingshu,Hong,Haiou,Zhang,Yang,et al. Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening[J]. BioMedical Engineering OnLine,2021,20.
APA	Ni,Jingshu.,Hong,Haiou.,Zhang,Yang.,Tang,Shiqi.,Han,Yongsheng.,...&Dong,Meili.(2021).Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening.BioMedical Engineering OnLine,20.
MLA	Ni,Jingshu,et al."Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening".BioMedical Engineering OnLine 20(2021).