Knowledge Management System of Hefei Institute of Physical Science,CAS
Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening | |
Ni,Jingshu1,2; Hong,Haiou4; Zhang,Yang1,2![]() ![]() ![]() ![]() ![]() ![]() | |
2021-06-01 | |
发表期刊 | BioMedical Engineering OnLine
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通讯作者 | Wang,YiKun(wyk@aiofm.ac.cn) ; Dong,Meili(dongmeili@aiofm.ac.cn) |
摘要 | AbstractBackgroundEstablishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an independent risk factor of early assessment of atherosclerotic risk.MethodsWe propose a non-invasive skin cholesterol detection method based on absorption spectroscopy. Detection reagents specifically bind to skin cholesterol and react with indicator to produce colored products, the skin cholesterol content can be obtained through absorption spectrum information on colored products detected by non-invasive technology. Gas chromatography is used to measure cholesterol extracted from the skin to verify the accuracy and reliability of the non-invasive test method. A total of 342 subjects were divided into normal group (n?=?115), disease group (n?=?110) and risk group (n?=?117). All subjects underwent non-invasive skin cholesterol test. The diagnostic accuracy of the measured value was analyzed by receiver-operating characteristic (ROC) curve.ResultsThe proposed method is able to identify porcine skin containing gradient concentration of cholesterol. The values measured by non-invasive detection method were significantly correlated with gas chromatography measured results (r?=?0.9074, n?=?73, p?0.001). Bland–Altman bias was ? 72.78?±?20.03 with 95% limits of agreement ? 112.05 to ? 33.51, falling within the prespecified clinically non-significant range. We further evaluated the method of patients with atherosclerosis and risk population as well as normal group, patients and risk atherosclerosis group exhibited higher skin cholesterol content than normal group (all P?0.001). The area under the ROC curve for distinguishing Normal/Disease group was 0.8642 (95% confidence interval, 0.8138 to 0.9146), meanwhile, the area under the ROC curve for distinguishing Normal/Risk group was 0.8534 (95% confidence interval, 0.8034 to 0.9034).ConclusionsThe method demonstrated its capability of detecting different concentration of skin cholesterol. This non-invasive skin cholesterol detection system may potentially be used as a risk assessment tool for atherosclerosis screening, especially for a large population. |
关键词 | Non-invasive Skin cholesterol Absorption spectroscopy Subclinical atherosclerosis |
DOI | 10.1186/s12938-021-00889-1 |
关键词[WOS] | CARDIOVASCULAR RISK ; TISSUE CHOLESTEROL ; PRIMARY PREVENTION ; BARRIER FUNCTION ; STRATUM-CORNEUM ; DERMATITIS ; INFLAMMATION ; ABSORPTION ; DEPOSITION ; DIGITONIN |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Science and Technology Major Project of Anhui Province of China[201903a07020027] ; Science and Technology Major Project of Anhui Province of China[17030801007] ; Science and Technology Major Project of Anhui Province of China[17030901017] ; Science and Technology Service Network Project, Chinese Academy of Sciences[KFJSTS-QYZD-184] ; Science and Technology Service Network Project, Chinese Academy of Sciences[KFF-STS-ZDTP-063] ; External Cooperation Program of the Bureau of International Cooperation, Chinese Academy of Sciences[116134KYSB20170018] ; Natural Science Foundation of Anhui Province of China[1908085QH365] ; Key research and Development Program of Anhui Province of China[1804b06020350] ; Key research and Development Program of Anhui Province of China[1804h08020291] ; Key research and Development Program of Anhui Province of China[202004a07020016] |
项目资助者 | Science and Technology Major Project of Anhui Province of China ; Science and Technology Service Network Project, Chinese Academy of Sciences ; External Cooperation Program of the Bureau of International Cooperation, Chinese Academy of Sciences ; Natural Science Foundation of Anhui Province of China ; Key research and Development Program of Anhui Province of China |
WOS研究方向 | Engineering |
WOS类目 | Engineering, Biomedical |
WOS记录号 | BMC:10.1186/s12938-021-00889-1 |
出版者 | BioMed Central |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/122290 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Wang,YiKun; Dong,Meili |
作者单位 | 1.Chinese Academy of Sciences; Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science 2.University of Science and Technology of China 3.Wanjiang Center for Development of Emerging Industrial Technology 4.First Affiliated Hospital of University of Science and Technology of China; Health Management Center 5.Renmin Hospital of WuHan University; Health Management Center 6.First Affiliated Hospital of University of Science and Technology of China; Department of Cardiovascular Medicine 7.The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine; Department of Endocrinology |
推荐引用方式 GB/T 7714 | Ni,Jingshu,Hong,Haiou,Zhang,Yang,et al. Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening[J]. BioMedical Engineering OnLine,2021,20. |
APA | Ni,Jingshu.,Hong,Haiou.,Zhang,Yang.,Tang,Shiqi.,Han,Yongsheng.,...&Dong,Meili.(2021).Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening.BioMedical Engineering OnLine,20. |
MLA | Ni,Jingshu,et al."Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening".BioMedical Engineering OnLine 20(2021). |
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