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A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery
Xiao, Jianmin1,2; Yan, Miao1,2; Zhou, Ke5; Chen, Hui4; Xu, Zhaowei3; Gan, Yuehao1,2; Hong, Biao1,2; Tian, Geng3; Qian, Junchao5; Zhang, Guilong3; Wu, Zhengyan1
2021-07-30
Source PublicationJOURNAL OF NANOBIOTECHNOLOGY
Corresponding AuthorQian, Junchao(qianjunchao@hmfl.ac.cn) ; Zhang, Guilong(glzhang@bzmc.edu.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn)
AbstractThe cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell membrane nanocarriers, indicating that BMMPs could deliver more drug into cancer cells. Subsequently, the BMMPs were coated with nanoselenium (Se), and subsequently loaded with Mn2+ ions and doxorubicin (DOX) to fabricate a functional nanoplatform (BMMP-Mn2+/Se/DOX). Notably, in this nanoplatform, Se nanoparticles activated superoxide dismutase-1 (SOD-1) expression and subsequently up-regulated downstream H2O2 levels. Next, the released Mn2+ ions catalyzed H2O2 to highly toxic hydroxyl radicals (center dot OH), inducing mitochondrial damage. In addition, the BMMP-Mn2+/Se nanoplatform inhibited glutathione peroxidase 4 (GPX4) expression and further accelerated intracellular reactive oxygen species (ROS) generation. Notably, the BMMP-Mn2+/Se/DOX nanoplatform exhibited increased effectiveness in inducing cancer cell death through mitochondrial and nuclear targeting dual-mode therapeutic pathways and showed negligible toxicity to normal organs. Therefore, this nanoplatform may represent a promising drug delivery system for achieving a safe, effective, and accurate cancer therapeutic plan.
KeywordCell membrane Reactive oxygen species Superoxide dismutase-1 Glutathione peroxidase 4 Dual-mode therapeutic pathways Drug delivery system
DOI10.1186/s12951-021-00971-9
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; DRUG-DELIVERY ; CANCER-THERAPY ; TOXICITY ; PLATFORM ; SYSTEM ; ACID ; TPGS
Indexed BySCI
Language英语
Funding ProjectScience and Technology Service Programs of Chinese Academy of Sciences[KFJ-STS-QYZD-115] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Natural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; National Natural Science Foundation of China[81630019] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
Funding OrganizationScience and Technology Service Programs of Chinese Academy of Sciences ; Taishan Scholars Construction Engineering ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation ; Special Project of Central Government for Local Science and Technology Development of Shandong Province ; Key Research and Development Plan of Shandong Province
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000679729900001
PublisherBMC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/123159
Collection中国科学院合肥物质科学研究院
Corresponding AuthorQian, Junchao; Zhang, Guilong; Wu, Zhengyan
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat, State Adm Tradit Chinese Med China, Yantai 264003, Peoples R China
4.Anhui Med Univ, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China
5.Chinese Acad Sci, Hefei Canc Hosp, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol,Hefei Inst Phys Sci, Hefei 230031, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Jianmin,Yan, Miao,Zhou, Ke,et al. A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery[J]. JOURNAL OF NANOBIOTECHNOLOGY,2021,19.
APA Xiao, Jianmin.,Yan, Miao.,Zhou, Ke.,Chen, Hui.,Xu, Zhaowei.,...&Wu, Zhengyan.(2021).A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery.JOURNAL OF NANOBIOTECHNOLOGY,19.
MLA Xiao, Jianmin,et al."A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery".JOURNAL OF NANOBIOTECHNOLOGY 19(2021).
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