Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma A SEER population-based study

doi:10.1097/MD.0000000000026629

HFCAS OpenIR

	Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma A SEER population-based study
	Lu, Yan1 ; Hua, Jianfeng 1; Yan, Fengqin 2,3,4,5; Jiang, Chuner 6; Piao, Yongfeng 2,3,4,5; Ye, Zhimin 2,3,4,5; Fu, Zhenfu 2,3,4,5; Jiang, Haitao 7; Wang, Fangzheng 2,3,4,5; Jiang, Yangming 8
	2021-07-23
发表期刊	MEDICINE
ISSN	0025-7974
通讯作者	Wang, Fangzheng(wangfz76@126.com)
摘要	Currently, the impact of chemotherapy (CT) on survival outcomes in elderly patients with nasopharyngeal carcinoma (NPC) receiving radiation therapy (RT) remains controversial. This retrospective study aims to investigate survival outcomes in a cohort of elderly NPC patients receiving RT alone or together with CT. Clinical data on 529 NPC patients aged 65 years and older extracted from the Surveillance, Epidemiology, and End Results registry (2004-2015) was collected and retrospectively reviewed. In this cohort, 74 patients were treated with RT alone and 455 individuals received RT and CT. We used propensity score matching with a 1:3 ratio to identify correlations between patients based on 6 different variables. Kaplan-Meier analysis was used to evaluate overall (OS) and cancer-specific survival (CSS). The differences in OS and CSS between the 2 treatment groups were compared using the Log-rank test and Cox proportional hazards models. The estimated 5-year OS and CSS rates for all patients were 49.5% and 59.3%, respectively. The combination of RT and CT provided longer OS than RT alone (53.7% vs 36.9%, P = .002), while no significant difference was observed in CSS (61.8% vs 51.7%, P = .074) between the 2 groups. Moreover, multivariate analysis demonstrated that the combination of CT and RT correlated favorably with OS and CSS. Subgroup analyses showed that the combination of RT and CT correlated better with both OS and CSS in patients with stage T3 or N2 or stage III. Among NPC patients aged 65 years and older, treatment with RT and CT provided longer OS than RT alone. Furthermore, the combination of RT and CT showed a better correlation with OS and CSS in NPC patients with stage T3 or N2 or stage III.
关键词	chemotherapy nasopharyngeal carcinoma radiation therapy SEER survival
DOI	10.1097/MD.0000000000026629
关键词[WOS]	INTENSITY-MODULATED RADIOTHERAPY ; PROPENSITY SCORE METHODS ; PHASE-III ; CONCURRENT CHEMORADIOTHERAPY ; ADJUVANT CHEMOTHERAPY ; CANCER ; SURVIVAL ; METAANALYSIS ; NEOADJUVANT ; EXPERIENCE
收录类别	SCI
语种	英语
资助项目	Medical and Health Science and Technology Program of Zhejiang Province[2020KY084] ; Medical and Health Science and Technology Program of Zhejiang Province[2019KY041] ; Medical and Health Science and Technology Program of Zhejiang Province[2013KYB033] ; Medical and Health Science and Technology Program of Zhejiang Province[2009B026] ; Medical and Health Science and Technology Program of Zhejiang Province[2006A016] ; Medical and Health Science and Technology Program of Zhejiang Province[2005B012] ; Medical and Health Science and Technology Program of Zhejiang Province[2004B014] ; National Natural Science Foundation of China[81502647] ; Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province (klab 2020)
项目资助者	Medical and Health Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of China ; Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province (klab 2020)
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:000675548800021
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/123288
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Fangzheng
作者单位	1.Kecheng Peoples Hosp, Dept Radiat Oncol, Quzhou, Zhejiang, Peoples R China 2.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Zhejiang, Peoples R China 4.Key Lab Head Neck Canc Translat Res Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China 5.Key Lab Radiat Oncol Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China 6.Univ Chinese Acad Sci, Dept Breast Tumor Surg, Canc Hosp, Hangzhou, Zhejiang, Peoples R China 7.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China 8.Chinese Acad Sci, Dept Digital Earth, Inst Remote Sensing & Digital Earth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lu, Yan,Hua, Jianfeng,Yan, Fengqin,et al. Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma A SEER population-based study[J]. MEDICINE,2021,100.
APA	Lu, Yan.,Hua, Jianfeng.,Yan, Fengqin.,Jiang, Chuner.,Piao, Yongfeng.,...&Jiang, Yangming.(2021).Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma A SEER population-based study.MEDICINE,100.
MLA	Lu, Yan,et al."Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma A SEER population-based study".MEDICINE 100(2021).