Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

doi:10.1155/2021/5526581

HFCAS OpenIR

	Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma
	Yang, Ke1,2 ; Wu, Ke 1; Feng, Jianguo 1; Yutian, Ling 1; Zhu, Xin 1,2; Xu, Dong 1,2
	2021-07-15
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1741-427X
通讯作者	Zhu, Xin(zhuxin@zjcc.org.cn) ; Xu, Dong(xudong@zjcc.org.cn)
摘要	Objective. To investigate the antitumor effect of andrographolide on the ATC cell lines 8505C and CAL62 and to explore the possible mechanism of the effect. Methods. CCK8 and colony formation assays were performed to detect proliferation. Cell migration was tested by scratch assay. Annexin V/PI staining was used to detect cell apoptosis and cell cycle. Glucose and lactic acid kits were carried out to evaluate the glycolysis level after andrographolide treatment. Western blot was used to detect the changes in the apoptosis-related proteins and glycolysis-related enzymes in both 8505C and CAL62 cells. Results. Treatment with 60 mu M andrographolide had significant effects on 8505C and CAL62, including inhibition of proliferation, inhibition of migration, arrest of the cell cycle, promotion of apoptosis, and inhibition of glycolysis. Conclusion. Andrographolide has an antitumor effect and can significantly affect glycolysis in ATC cells.
DOI	10.1155/2021/5526581
关键词[WOS]	APOPTOSIS ; INHIBITION ; ANTICANCER ; ACTIVATION
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82072950]
项目资助者	National Natural Science Foundation of China
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000680521900006
出版者	HINDAWI LTD
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/124339
专题	中国科学院合肥物质科学研究院
通讯作者	Zhu, Xin; Xu, Dong
作者单位	1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China 2.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yang, Ke,Wu, Ke,Feng, Jianguo,et al. Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,2021.
APA	Yang, Ke,Wu, Ke,Feng, Jianguo,Yutian, Ling,Zhu, Xin,&Xu, Dong.(2021).Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021.
MLA	Yang, Ke,et al."Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021(2021).