CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer

doi:10.1073/pnas.2012881118

HFCAS OpenIR

	CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer
	Wang, Xiaolin1,2,3,4 ; Li, Jingxin 2; Bian, Xing 1,2,3,4; Wu, Cheng; Hua, Jinghan 1,2,3,4; Chang, Shuhui 2; Yu, Tianyi 2; Li, Hong 1,3,4; Li, Yongxiang 5; Hu, Shanshan 6; Shan, Ge 2; Lin, Wenchu 1,3,4
	2021-08-17
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
通讯作者	Hu, Shanshan(hss923@ustc.edu.cn) ; Shan, Ge(shange@ustc.edu.cn) ; Lin, Wenchu(wenchu@hmfl.ac.cn)
摘要	Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI7 back-spliced from exons 3 and 4 of unconventional prefoldin RPB5 interactor 1 (URI1) from circRNA profiling of five-paired human gastric and the corresponding nontu-mor adjacent specimens (paraGC). CircURI7 exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. Mechanistically, circURI7 directly interacts with heterogeneous nu-clear ribonucleoprotein M (hnRNPM) to modulate alternative splicing of genes, involved in the process of cell migration, thus suppressing GC metastasis. Collectively, our study expands the current knowledge regarding the molecular mechanism of circRNA-mediated cancer me-tastasis via modulating alternative splicing.
关键词	circURI1 cancer metastasis hnRNPM splicing
DOI	10.1073/pnas.2012881118
关键词[WOS]	LONG NONCODING RNAS ; CIRCULAR RNAS ; UNIQUE FEATURES ; MESSENGER-RNA ; EXPRESSION ; PROTEINS ; ADENOCARCINOMA ; PROLIFERATION ; INVASION ; ABUNDANT
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2019YFA0802600] ; National Key Research and Development Program of China[2018YFC1004500] ; National Natural Science Foundation of China[81972191] ; National Natural Science Foundation of China[81902525] ; National Natural Science Foundation of China[81672647] ; National Natural Science Foundation of China[31930019] ; National Natural Science Foundation of China[31725016] ; National Natural Science Foundation of China[91940303] ; Science and Technology Major Project of Anhui Province[18030801140] ; Strategic Priority Research Program Biological basis of aging and therapeutic strategies of the Chinese Academy of Sciences[XDB39010400] ; 100-Talent Program of Chinese Academy of Sciences
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Science and Technology Major Project of Anhui Province ; Strategic Priority Research Program Biological basis of aging and therapeutic strategies of the Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000687403700015
出版者	NATL ACAD SCIENCES
引用统计	被引频次：69[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/124454
专题	中国科学院合肥物质科学研究院
通讯作者	Hu, Shanshan; Shan, Ge; Lin, Wenchu
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 4.High Magnet Field Lab Anhui Prov, Hefei 230031, Peoples R China 5.Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hefei 230022, Peoples R China 6.Univ Sci & Technol China, Div Life Sci & Med, Dept Neurosurg, Hefei 230001, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiaolin,Li, Jingxin,Bian, Xing,et al. CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118.
APA	Wang, Xiaolin.,Li, Jingxin.,Bian, Xing.,Wu, Cheng.,Hua, Jinghan.,...&Lin, Wenchu.(2021).CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118.
MLA	Wang, Xiaolin,et al."CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(2021).