Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer

doi:10.1016/j.biomaterials.2021.121057

HFCAS OpenIR

	Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer
	Zhang, Hao 1; Xu, Shengduo 1; Zhang, Jishen 1; Wang, Zifeng 1; Liu, Dingxin 1; Guo, Li 1; Cheng, Cheng 2,3,4; Cheng, Yilong 5; Xu, Dehui 1; Kong, Michael G.1,6; Rong, Mingzhe 1; Chu, Paul K.3,4
	2021-09-01
发表期刊	BIOMATERIALS
ISSN	0142-9612
通讯作者	Liu, Dingxin(liudingxin@mail.xjtu.edu.cn)
摘要	Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.
关键词	Post-operative tumor treatment Surface discharge plasma Reactive oxygen species Plasma-activated biogel
DOI	10.1016/j.biomaterials.2021.121057
关键词[WOS]	ADJUVANT CHEMOTHERAPY ; COLD-PLASMA ; DNA-DAMAGE ; CELL-DEATH ; SURGERY ; HEAD
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51907158] ; National Natural Science Foundation of China[51677147] ; National Natural Science Foundation of China[51837008] ; City University of Hong Kong Strategic Research Grant (SRG)[7005264]
项目资助者	National Natural Science Foundation of China ; City University of Hong Kong Strategic Research Grant (SRG)
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000690437900002
出版者	ELSEVIER SCI LTD
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/125111
专题	中国科学院合肥物质科学研究院
通讯作者	Liu, Dingxin
作者单位	1.Xi An Jiao Tong Univ, Ctr Plasma Biomed, State Key Lab Elect Insulat & Power Equipment, Xian 710049, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Plasma Phys, POB 1126, Hefei 230031, Anhui, Peoples R China 3.City Univ Hong Kong, Dept Mat Sci & Engn, Dept Phys, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China 4.City Univ Hong Kong, Dept Biomed Engn, Tat Chee Ave, Hong Kong, Peoples R China 5.Xi An Jiao Tong Univ, Sch Sci, Dept Appl Phys, Xian 710049, Shaanxi, Peoples R China 6.Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA
推荐引用方式 GB/T 7714	Zhang, Hao,Xu, Shengduo,Zhang, Jishen,et al. Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer[J]. BIOMATERIALS,2021,276.
APA	Zhang, Hao.,Xu, Shengduo.,Zhang, Jishen.,Wang, Zifeng.,Liu, Dingxin.,...&Chu, Paul K..(2021).Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer.BIOMATERIALS,276.
MLA	Zhang, Hao,et al."Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer".BIOMATERIALS 276(2021).