Explore the Value of Adding Induction Chemotherapy to Concurrent Chemoradiotherapy in T3-4N0M0 Nasopharyngeal Carcinoma Patients: A Retrospective Study

doi:10.2147/CMAR.S321471

HFCAS OpenIR

	Explore the Value of Adding Induction Chemotherapy to Concurrent Chemoradiotherapy in T3-4N0M0 Nasopharyngeal Carcinoma Patients: A Retrospective Study
	Li, Peijing 1,2; Zhang, Qun 3; Luo, Donghua 4,5,6; Jiang, Feng1,2 ; Jin, Qifeng 1,2; Hua, Yonghong 1,2; Jin, Ting 1,2; Chen, Xiaozhong 1,2
	2021
发表期刊	CANCER MANAGEMENT AND RESEARCH
ISSN	1179-1322
通讯作者	Jin, Ting(jinting22222@163.com) ; Chen, Xiaozhong(chenxiaozhong2016@163.com)
摘要	Purpose: Patients with T3-4N0M0 nasopharyngeal carcinoma (NPC) are a unique subgroup of locoregional advanced NPC, which generally have a better prognosis than others and are often excluded in most randomized controlled clinical trials focusing on locoregional advanced NPC. The management of this population is still controversial. This study aims to evaluate the outcomes of T3-4N0M0 NPC patients treated with sequential induction chemotherapy and concurrent chemoradiotherapy (IC+CCRT) or chemoradiotherapy (CCRT) alone. Patients and Methods: We included 362 patients diagnosed with T3-4N0M0 NPC from two hospitals between December 2005 and December 2014. All patients were received IC + CCRT (n=146) or CCRT (n=216). Locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were retrospectively estimated. Results: The median follow-up was 95 (range: 11-168) months. Univariable analyses have shown that 5-year LRFFS, DFS and OS in the IC+CCRT group and the CCRT group were 87.4% vs 93.4% (P = 0.035), 80.4% vs 87.0% (P = 0.047) and 86.3% vs 93.0% (P = 0.040). Multivariate analyses demonstrated that only the T stage was the independent prognostic factor for LRFFS, DFS, and OS in the entire group analysis. Subgroup analysis revealed that patients with T3 tumors who received IC+CCRT had significantly lower LRFFS, DFS, and OS than those treated with CCRT. For T4 patients, the outcomes had no significant difference between the two groups. Conclusion: This retrospective study showed that T3N0M0 patients who received CCRT had better prognosis than those treated with IC+CCRT. In terms of T4N0M0 disease, treatment outcomes are similar in both treatment groups. However, these results require further confirmation of large sample size, prospectively, randomized controlled trials.
关键词	nasopharyngeal carcinoma chemotherapy intensity-modulated radiation therapy
DOI	10.2147/CMAR.S321471
关键词[WOS]	RADIOTHERAPY ; MULTICENTER ; CANCER ; TRIAL
收录类别	SCI
语种	英语
资助项目	Zhejiang Province Medical and Health Science and Technology Project[2021KY596] ; Zhejiang Province Medical and Health Science and Technology Project[2018KY315] ; Medical Science and Technology Research Projects of Health Commission of Guangdong Province[A2020606]
项目资助者	Zhejiang Province Medical and Health Science and Technology Project ; Medical Science and Technology Research Projects of Health Commission of Guangdong Province
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000696641900003
出版者	DOVE MEDICAL PRESS LTD
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/125340
专题	中国科学院合肥物质科学研究院
通讯作者	Jin, Ting; Chen, Xiaozhong
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Radiat Oncol, Hangzhou 310022, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310000, Zhejiang, Peoples R China 3.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China 4.Sun Yat Sen Univ, Dept Nasopharyngeal Carcinoma, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China 5.State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China 6.Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Li, Peijing,Zhang, Qun,Luo, Donghua,et al. Explore the Value of Adding Induction Chemotherapy to Concurrent Chemoradiotherapy in T3-4N0M0 Nasopharyngeal Carcinoma Patients: A Retrospective Study[J]. CANCER MANAGEMENT AND RESEARCH,2021,13.
APA	Li, Peijing.,Zhang, Qun.,Luo, Donghua.,Jiang, Feng.,Jin, Qifeng.,...&Chen, Xiaozhong.(2021).Explore the Value of Adding Induction Chemotherapy to Concurrent Chemoradiotherapy in T3-4N0M0 Nasopharyngeal Carcinoma Patients: A Retrospective Study.CANCER MANAGEMENT AND RESEARCH,13.
MLA	Li, Peijing,et al."Explore the Value of Adding Induction Chemotherapy to Concurrent Chemoradiotherapy in T3-4N0M0 Nasopharyngeal Carcinoma Patients: A Retrospective Study".CANCER MANAGEMENT AND RESEARCH 13(2021).