Knowledge Management System of Hefei Institute of Physical Science,CAS
Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum | |
Li, Pan1; Zhou, Binbin4; Ge, Meihong1; Jing, Xianghong3; Yang, Liangbao1,2 | |
2022-01-15 | |
发表期刊 | TALANTA |
ISSN | 0039-9140 |
通讯作者 | Jing, Xianghong(jingxh@mail.cintcm.ac.cn) ; Yang, Liangbao(lbyang@iim.ac.cn) |
摘要 | Sensitivity and credibility detecting histamine (HA) as an important neurotransmitter in biofluids is of importance in analytical science and physiology. Surface-enhanced Raman spectroscopy (SERS) is able to realize the high sensitivity with single molecules level, but providing the high sensitivity for HA with a small cross section remains a challenge. Here we develop the metal complex-based SERS nanoprobe nitrilotriacetic acid-Ni2+ (NTA-Ni2+) combined with self-assemble Au NPs active substrates for sensitive detection of HA. The NTA-Ni2+ can capture the HA molecules close to Au NPs substrates and then amplify the Raman signals of HA owing to the formation of a complex of NTA-Ni2+-HA. The self-assemble Au film through the evaporation-driven method can provide the high-density hot spots substrate with high stability and reproducibility. The NTA-Ni2+ decorated Au NPs as nanoprobe responds to HA with 1 mu M level of sensitivity. More importantly, the developed SERS nanoprobe composing of NTA-Ni2+ and self-assemble Au NPs can be utilized to detect and monitor the HA spiked into serum, indicating the potential prospect in analysis of HA in complex specimen. |
关键词 | SERS Metal coordination SERS nanoprobe Neurotransmitter Histamine |
DOI | 10.1016/j.talanta.2021.122913 |
关键词[WOS] | ENHANCED RAMAN-SPECTROSCOPY ; BLOOD-PLASMA ; SURFACE ; RESONANCE ; SCATTERING ; FISH ; SUBSTRATE ; ARRAYS |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Nature Science Research Project of Anhui Province[1908085QB65] ; National Science Foundation of China[21974142] |
项目资助者 | Nature Science Research Project of Anhui Province ; National Science Foundation of China |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Analytical |
WOS记录号 | WOS:000705224700005 |
出版者 | ELSEVIER |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/125494 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Jing, Xianghong; Yang, Liangbao |
作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Anhui, Peoples R China 2.Hefei Canc Hosp, Chinese Acad Sci, Dept Pharm, Hefei 230031, Anhui, Peoples R China 3.China Acad Chinese Med, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China 4.City Univ Hong Kong, Dept Mech Engn, Kowloon, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Pan,Zhou, Binbin,Ge, Meihong,et al. Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum[J]. TALANTA,2022,237. |
APA | Li, Pan,Zhou, Binbin,Ge, Meihong,Jing, Xianghong,&Yang, Liangbao.(2022).Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum.TALANTA,237. |
MLA | Li, Pan,et al."Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum".TALANTA 237(2022). |
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