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Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum
Li, Pan1; Zhou, Binbin4; Ge, Meihong1; Jing, Xianghong3; Yang, Liangbao1,2
2022-01-15
Source PublicationTALANTA
ISSN0039-9140
Corresponding AuthorJing, Xianghong(jingxh@mail.cintcm.ac.cn) ; Yang, Liangbao(lbyang@iim.ac.cn)
AbstractSensitivity and credibility detecting histamine (HA) as an important neurotransmitter in biofluids is of importance in analytical science and physiology. Surface-enhanced Raman spectroscopy (SERS) is able to realize the high sensitivity with single molecules level, but providing the high sensitivity for HA with a small cross section remains a challenge. Here we develop the metal complex-based SERS nanoprobe nitrilotriacetic acid-Ni2+ (NTA-Ni2+) combined with self-assemble Au NPs active substrates for sensitive detection of HA. The NTA-Ni2+ can capture the HA molecules close to Au NPs substrates and then amplify the Raman signals of HA owing to the formation of a complex of NTA-Ni2+-HA. The self-assemble Au film through the evaporation-driven method can provide the high-density hot spots substrate with high stability and reproducibility. The NTA-Ni2+ decorated Au NPs as nanoprobe responds to HA with 1 mu M level of sensitivity. More importantly, the developed SERS nanoprobe composing of NTA-Ni2+ and self-assemble Au NPs can be utilized to detect and monitor the HA spiked into serum, indicating the potential prospect in analysis of HA in complex specimen.
KeywordSERS Metal coordination SERS nanoprobe Neurotransmitter Histamine
DOI10.1016/j.talanta.2021.122913
WOS KeywordENHANCED RAMAN-SPECTROSCOPY ; BLOOD-PLASMA ; SURFACE ; RESONANCE ; SCATTERING ; FISH ; SUBSTRATE ; ARRAYS
Indexed BySCI
Language英语
Funding ProjectNature Science Research Project of Anhui Province[1908085QB65] ; National Science Foundation of China[21974142]
Funding OrganizationNature Science Research Project of Anhui Province ; National Science Foundation of China
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000705224700005
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/125494
Collection中国科学院合肥物质科学研究院
Corresponding AuthorJing, Xianghong; Yang, Liangbao
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Anhui, Peoples R China
2.Hefei Canc Hosp, Chinese Acad Sci, Dept Pharm, Hefei 230031, Anhui, Peoples R China
3.China Acad Chinese Med, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China
4.City Univ Hong Kong, Dept Mech Engn, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li, Pan,Zhou, Binbin,Ge, Meihong,et al. Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum[J]. TALANTA,2022,237.
APA Li, Pan,Zhou, Binbin,Ge, Meihong,Jing, Xianghong,&Yang, Liangbao.(2022).Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum.TALANTA,237.
MLA Li, Pan,et al."Metal coordination induced SERS nanoprobe for sensitive and selective detection of histamine in serum".TALANTA 237(2022).
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