Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals

doi:10.1186/s41021-021-00214-1

HFCAS OpenIR

	Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals
	Zheng,Yuanyuan; Zhang,Fangrong; Xu,Shengmin; Wu,Lijun
	2021-09-22
发表期刊	Genes and Environment
通讯作者	Wu,Lijun(ljw@ipp.ac.cn)
摘要	AbstractDue to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditional animal models, which have various limitations such as species differences, expensive and time-consuming. Meanwhile, in vitro two-dimensional (2D) cultured cells or three-dimensional (3D) cultured neurospheres cannot fully simulate complex 3D structure of neural tissues. Recent advancements in neural organoid systems provides excellent models for the testing of environmental chemicals that affect the development of human CNS. Neural organoids derived from hPSCs not only can simulate the process of CNS development, including early stage neural tube formation, neuroepithelium differentiation and regional specification, but also its 3D structure, thus can be used to evaluate the effect of chemicals on differentiation and morphogenesis. Here, we provide a review of recent progress in the methods of culturing neural organoids and their applications in neurotoxicity testing of environmental chemicals. We conclude by highlighting challenge and future directions in neurotoxicity testing based on neural organoids.
关键词	CNS hPSC Neural organoids Neurotoxicity testing Environmental chemicals
DOI	10.1186/s41021-021-00214-1
语种	英语
WOS记录号	BMC:10.1186/s41021-021-00214-1
出版者	BioMed Central
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/125660
专题	中国科学院合肥物质科学研究院
通讯作者	Wu,Lijun
作者单位	Anhui University; Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology
推荐引用方式 GB/T 7714	Zheng,Yuanyuan,Zhang,Fangrong,Xu,Shengmin,et al. Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals[J]. Genes and Environment,2021,43.
APA	Zheng,Yuanyuan,Zhang,Fangrong,Xu,Shengmin,&Wu,Lijun.(2021).Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals.Genes and Environment,43.
MLA	Zheng,Yuanyuan,et al."Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals".Genes and Environment 43(2021).