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The Anti-Depressive Effects of Ultra-High Static Magnetic Field
Lv, Yue1,2; Fan, Yixiang1,2; Tian, Xiaofei3,4; Yu, Biao1,2; Song, Chao1,2; Feng, Chuanlin1,2; Zhang, Lei1,2; Ji, Xinmiao1,2; Zablotskii, Vitalii5,6; Zhang, Xin1,2,3,4,6
2021-12-18
Source PublicationJOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN1053-1807
Corresponding AuthorZhang, Xin(xinzhang@hmfl.ac.cn)
AbstractBackground Ultra-high field magnetic resonance imaging (MRI) has obvious advantages in acquiring high-resolution images. 7 T MRI has been clinically approved and 21.1 T MRI has also been tested on rodents. Purpose To examine the effects of ultra-high field on mice behavior and neuron activity. Study Type Prospective, animal model. Animal Model Ninety-eight healthy C57BL/6 mice and 18 depression model mice. Field Strength 11.1-33.0 T SMF (static magnetic field) for 1 hour and 7 T for 8 hours. Gradients were not on and no imaging sequence was used. Assessment Open field test, elevated plus maze, three-chambered social test, Morris water maze, tail suspension test, sucrose preference test, blood routine, biochemistry examinations, enzyme-linked immunosorbent assay, immunofluorescent assay. Statistical Tests The normality of the data was assessed by Shapiro-Wilk test, followed by Student's t test or the Mann-Whitney U test for statistical significance. The statistical cut-off line is P < 0.05. Results Compared to the sham group, healthy C57/6 mice spent more time in the center area (35.12 +/- 4.034, increased by 47.19%) in open field test and improved novel index (0.6201 +/- 0.02522, increased by 16.76%) in three-chambered social test a few weeks after 1 hour 11.1-33.0 T SMF exposure. 7 T SMF exposure for 8 hours alleviated the depression state of depression mice, including less immobile time in tail suspension test (58.32% reduction) and higher sucrose preference (increased by 8.80%). Brain tissue analysis shows that 11.1-33.0 T and 7 T SMFs can increase oxytocin by 164.65% and 36.03%, respectively. Moreover, the c-Fos level in hippocampus region was increased by 14.79%. Data Conclusion 11.1-33.0 T SMFs exposure for 1 hour or 7 T SMF exposure for 8 hours did not have detrimental effects on healthy or depressed mice. Instead, these ultra-high field SMFs have anti-depressive potentials. Evidence Level 1 Technical Efficacy Stage 1
Keywordultra-high field magnetic resonance imaging (MRI) static magnetic field (SMF) safety depression behavioral tests
DOI10.1002/jmri.28035
WOS KeywordANXIETY-LIKE BEHAVIOR ; C-FOS ; MRI ; NEUROGENESIS ; EXPOSURE ; SAFETY ; BRAIN
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[U21A20148] ; National Natural Science Foundation of China[52007185] ; Heye Health Technology Foundation[HYJJ20190801] ; National Science Foundation of Anhui Province[2019B365] ; China Postdoctoral Science Foundation[2019M662213] ; High Magnetic Field Laboratory of Anhui Province
Funding OrganizationNational Natural Science Foundation of China ; Heye Health Technology Foundation ; National Science Foundation of Anhui Province ; China Postdoctoral Science Foundation ; High Magnetic Field Laboratory of Anhui Province
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000731302200001
PublisherWILEY
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/126435
Collection中国科学院合肥物质科学研究院
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci Hefei China, Key Lab High Magnet Field & Ion Beam Phys Biol, High Magnet Field Lab, Hefei Inst Phys Sci, Hefei, Peoples R China
2.Univ Sci & Technol China, Sci Isl Branch Grad Sch, Hefei, Peoples R China
3.Anhui Univ, Inst Phys Sci, Hefei, Peoples R China
4.Anhui Univ, Inst Informat Technol, Hefei, Peoples R China
5.Czech Acad Sci, Inst Phys, Prague, Czech Republic
6.Int Magnetobiol Frontier Res Ctr, Hefei, Peoples R China
Recommended Citation
GB/T 7714
Lv, Yue,Fan, Yixiang,Tian, Xiaofei,et al. The Anti-Depressive Effects of Ultra-High Static Magnetic Field[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2021.
APA Lv, Yue.,Fan, Yixiang.,Tian, Xiaofei.,Yu, Biao.,Song, Chao.,...&Zhang, Xin.(2021).The Anti-Depressive Effects of Ultra-High Static Magnetic Field.JOURNAL OF MAGNETIC RESONANCE IMAGING.
MLA Lv, Yue,et al."The Anti-Depressive Effects of Ultra-High Static Magnetic Field".JOURNAL OF MAGNETIC RESONANCE IMAGING (2021).
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