HFCAS OpenIR
Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer
Gan, Yuehao1,2; Zhang, Jia1; Lei, Shulai4; Yan, Miao3; Xie, Wenteng1,2; Qi, Xiangyu3; Wang, Huijuan2; Xiao, Jianmin3; Chen, Siyang; Li, Shujuan; Tian, Geng3; Zhang, Guilong3; Wu, Zhengyan1
2022-02-01
Source PublicationCHEMICAL ENGINEERING JOURNAL
ISSN1385-8947
Corresponding AuthorZhang, Guilong(glzhang@bzmc.edu.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn)
AbstractThe use of multi-domain magnetic iron oxide nanoclusters (MMIONs) as Magnetic resonance imaging (MRI) contrast agent is facing problems of strong ferromagnetism and thus weak T-2 contrast ability. The doping of Gd ions holds potential to solve these problems by reducing ferromagnetism and enhancing transverse relaxivity (r(2)), but the exact role of doping in modulating the contrast properties remain unknown. Herein, we prepared a series of atomically precise GdxFe3-xO4 nanoclusters and systematically explored the effect of Gd doping on tuning their morphology, magnetic property, and r(2) value. After the doping of Gd ions, the specific surface area of GdxFe3-xO4 nanoclusters significantly increased, and meanwhile, the magnetic property of GdxFe3-xO4 nanoclusters transformed from ferromagnetism to superparamagnetism, which led to stronger T-2 contrast. Specifically, the highest r(2) value was obtained at 488 mM(-1)s(-1) (7.0 T) for Gd0.072Fe2.928O4 nanocluster, four times higher than that for pristine Fe3O4 (110 mM(-1)s(-1)). For potential applications, we validated the outstanding contrast of Gd0.018Fe2.982O4 nanocluster (r(2) = 481 mM(-1)s(-1) at 7.0 T) to diagnose early orthotopic cancer in mice. This work opens up a new avenue for the development of atomically precise Gd-doped MMIONs as efficient T-2-weighted MRI contrast agents.
KeywordGd doping Magnetic iron oxide nanoclusters Atomically precise MRI T-2-weighted contrast agents
DOI10.1016/j.cej.2021.132255
WOS KeywordTOTAL-ENERGY CALCULATIONS ; IRON-OXIDE NANOPARTICLES ; PROSTATE-CANCER ; PERFORMANCE ; MRI ; DELIVERY ; SIZE
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[22007006] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
Funding OrganizationNatural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Special Project of Central Government for Local Science and Technology Development of Shandong Province ; Taishan Scholars Construction Engineering ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
WOS IDWOS:000728529900001
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/126453
Collection中国科学院合肥物质科学研究院
Corresponding AuthorZhang, Guilong; Wu, Zhengyan
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Engn & Mat Sci Expt Ctr, Hefei 230026, Peoples R China
3.Binzhou Med Univ, Key Lab Prescript Effect & Clin Evaluat State Adm, Sch Pharm, Yantai 264003, Peoples R China
4.Hubei Univ Arts & Sci, Hubei Key Lab Low Dimens Optoelect Mat & Devices, Xiangyang 441053, Peoples R China
Recommended Citation
GB/T 7714
Gan, Yuehao,Zhang, Jia,Lei, Shulai,et al. Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer[J]. CHEMICAL ENGINEERING JOURNAL,2022,429.
APA Gan, Yuehao.,Zhang, Jia.,Lei, Shulai.,Yan, Miao.,Xie, Wenteng.,...&Wu, Zhengyan.(2022).Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer.CHEMICAL ENGINEERING JOURNAL,429.
MLA Gan, Yuehao,et al."Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer".CHEMICAL ENGINEERING JOURNAL 429(2022).
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