Knowledge Management System of Hefei Institute of Physical Science,CAS
NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer | |
He, Xiangming1,2; Gu, Jinping3; Zou, Dehong2; Yang, Hongjian2; Zhang, Yongfang2; Ding, Yuqing2; Teng, Lisong1 | |
2021-11-02 | |
发表期刊 | FRONTIERS IN MOLECULAR BIOSCIENCES |
通讯作者 | Teng, Lisong(lsteng@zju.edu.cn) |
摘要 | Triple-negative breast cancer (TNBC) is the most fatal type of breast cancer (BC). Due to the lack of relevant targeted drug therapy, in addition to surgery, chemotherapy is still the most common treatment option for TNBC. TNBC is heterogeneous, and different patients have an unusual sensitivity to chemotherapy. Only part of the patients will benefit from chemotherapy, so neoadjuvant chemotherapy (NAC) is controversial in the treatment of TNBC. Here, we performed an NMR spectroscopy-based metabolomics study to analyze the relationship between the patients' metabolic phenotypes and chemotherapy sensitivity in the serum samples. Metabolic phenotypes from patients with pathological partial response, pathological complete response, and pathological stable disease (pPR, pCR, and pSD) could be distinguished. Furthermore, we conducted metabolic pathway analysis based on identified significant metabolites and revealed significantly disturbed metabolic pathways closely associated with three groups of TNBC patients. We evaluated the discriminative ability of metabolites related to significantly disturbed metabolic pathways by using the multi-receiver-operating characteristic (ROC) curve analysis. Three significantly disturbed metabolic pathways of glycine, serine, and threonine metabolism, valine, leucine, and isoleucine biosynthesis, and alanine, aspartate, and glutamate metabolism could be used as potential predictive models to distinguish three types of TNBC patients. These results indicate that a metabolic phenotype could be used to predict whether a patient is suitable for NAC. Metabolomics research could provide data in support of metabolic phenotypes for personalized treatment of TNBC. |
关键词 | metabolomics triple-negative breast cancer metabolic pathway ROC curve NMR spectroscopy |
DOI | 10.3389/fmolb.2021.708052 |
关键词[WOS] | AMINO-ACID-METABOLISM ; HISTAMINE ; TISSUES ; IDENTIFICATION ; METABONOMICS ; CELLS ; SERUM |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China Youth Science Fund Project[21906147] ; Natural Science Foundation of Zhejiang Province, China[LQ18B050003] ; Zhejiang Provincial Medical and Health Science and Technology Program[2020KY489] |
项目资助者 | National Natural Science Foundation of China Youth Science Fund Project ; Natural Science Foundation of Zhejiang Province, China ; Zhejiang Provincial Medical and Health Science and Technology Program |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000719635900001 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/126623 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Teng, Lisong |
作者单位 | 1.Zhejiang Univ, Affiliated Hosp 1, Sch Med FAHZU, Hangzhou, Peoples R China 2.Chinese Acad Sci, Canc Hosp, Inst Basic Med & Canc IBMC, Univ Chinese Acad Sci,Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipm, Minist Educ, Hangzhou, Peoples R China |
推荐引用方式 GB/T 7714 | He, Xiangming,Gu, Jinping,Zou, Dehong,et al. NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8. |
APA | He, Xiangming.,Gu, Jinping.,Zou, Dehong.,Yang, Hongjian.,Zhang, Yongfang.,...&Teng, Lisong.(2021).NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer.FRONTIERS IN MOLECULAR BIOSCIENCES,8. |
MLA | He, Xiangming,et al."NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论