Current status of total neoadjuvant therapy for locally advanced rectal cancer

doi:10.1111/ajco.13640

HFCAS OpenIR

	Current status of total neoadjuvant therapy for locally advanced rectal cancer
	Feng, Wei 1,2; Yu, Bin 3,4; Zhang, Zhenya 3,4; Li, Juan 4,5,6,7; Wang, Yuxiang 4,5,6,7
	2021-11-24
发表期刊	ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
ISSN	1743-7555
通讯作者	Wang, Yuxiang(wyxhbs69@163.com)
摘要	Neoadjuvant chemoradiotherapy (nCRT) plus total mesorectal excision (TME) has been the standard regimen for treatment of patients with locally advanced rectal cancer (LARC), because it significantly reduces the rate of local recurrence and enables sphincter preservation. However, distant metastasis remains the major reason for treatment failure, and the value of postoperative chemotherapy is still controversial. Recent studies have examined the use of total neoadjuvant therapy (TNT), defined as induction and/or consolidation chemotherapy (CONCT) with radiotherapy (RT) or nCRT prior to surgery. The results indicated that TNT may increase the rates of chemotherapy compliance and pathological complete response (pCR), and probably improve the success rate of sphincter preservation surgery. TNT may also improve disease-free survival and overall survival, and even reduce the rate of relapse. Here, we critically appraise the existing literature on three different TNT schemes used for LARC patients.
关键词	chemoradiation therapy chemotherapy disease-free survival (DFS) pathological complete response (pCR) rectal cancer sphincter preservation
DOI	10.1111/ajco.13640
关键词[WOS]	TOTAL MESORECTAL EXCISION ; PHASE-III TRIAL ; HIGH-RISK ; PREOPERATIVE CHEMORADIOTHERAPY ; OPEN-LABEL ; INDUCTION CHEMOTHERAPY ; ADJUVANT CHEMOTHERAPY ; RADIATION-THERAPY ; POSTOPERATIVE CHEMORADIOTHERAPY ; CONCOMITANT CHEMORADIOTHERAPY
收录类别	SCI
语种	英语
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000721908300001
出版者	WILEY
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/126667
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yuxiang
作者单位	1.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou, Peoples R China 2.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 3.Hebei Med Univ, Dept Surg 2, Affiliated Hosp 4, Shijiazhuang, Hebei, Peoples R China 4.Hebei Prov Tumor Hosp, Shijiazhuang 050011, Hebei, Peoples R China 5.Hebei Med Univ, Dept Radiat Oncol, Affiliated Hosp 4, Shijiazhuang, Hebei, Peoples R China 6.Hebei Clin Res Ctr Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China 7.Hebei Med Univ, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Feng, Wei,Yu, Bin,Zhang, Zhenya,et al. Current status of total neoadjuvant therapy for locally advanced rectal cancer[J]. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY,2021.
APA	Feng, Wei,Yu, Bin,Zhang, Zhenya,Li, Juan,&Wang, Yuxiang.(2021).Current status of total neoadjuvant therapy for locally advanced rectal cancer.ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY.
MLA	Feng, Wei,et al."Current status of total neoadjuvant therapy for locally advanced rectal cancer".ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2021).