HFCAS OpenIR
Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy
Liu, Jin1,2,3; Wang, Wenjuan2,4,5; Zhou, Yanfei1,3; Gan, Chen3; Wang, Tengfei1,3; Hu, Zongtao1,3; Lou, Jianjun1,3; Wang, Hongzhi1,3; Yang, Li-Zhuang1,3; Wong, Stephen T. C.6,7; Li, Hai1,3
2021-12-02
Source PublicationJOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN1053-1807
Corresponding AuthorYang, Li-Zhuang(lzyang@ustc.edu.cn) ; Li, Hai(hli@cmpt.ac.cn)
AbstractBackground Patients receiving cranial radiation face the risk of delayed brain dysfunction. However, an early medical imaging marker is not available until irreversible morphological changes emerge. Purpose To explore the micromorphological white matter changes during the radiotherapy session by utilizing an along-tract analysis framework. Study Type Prospective. Population Eighteen nasopharyngeal carcinoma (two female) patients receiving cranial radiation. Field Strength/Sequence 3.0 T; Diffusion tensor imaging (DTI) and T1- and T2-weighted images (T1W, T2W); computed tomography (CT). Assessment Patients received three DTI imaging scans during the radiotherapy (RT), namely the baseline scan (1-2 days before RT began), the middle scan (the middle of the RT session), and the end scan (1-2 days after RT ended). Twelve fibers were segmented after whole-brain tractography. Then, the fractional anisotropy (FA) values and the cumulative radiation dose received for each fiber streamline were resampled and projected into their center fiber. Statistical Tests The contrast among the three scans (P1: middle scan-baseline scan; P2: end scan-middle scan; P3: end scan-baseline scan) were compared using the linear mixed model for each of the 12 center fibers. Then, a dose-responsiveness relationship was performed using Pearson correlation. P < 0.05 was considered statistically significant. Results Six of the 12 center fibers showed significant changes of FA values during the RT but with heterogeneous patterns. The significant changes along a specific center fiber were associated with their cumulative dose received (Genu: P1 r = -0.6182, P2 r = -0.5907; Splenium: P1 r = 0.4055, P = 0.1063, P2 r = 0.6742; right uncinate fasciculus: P1 r = -0.3865, P2 r = -0.4912, P = 0.0533; right corticospinal tract: P1 r = 0.4273, P = 0.1122, P2 r = -0.6885). Data Conclusion The along-tract analysis might provide sensitive measures on the early-onset micromorphological changes. Level of Evidence 2 Technical Efficacy Stage 3
Keywordnasopharyngeal carcinoma along-tract analysis diffusion tensor imaging radiotherapy radiation-induced brain injury imaging biomarkers
DOI10.1002/jmri.28018
WOS KeywordINDUCED BRAIN-INJURY ; DIFFUSION TENSOR ; NASOPHARYNGEAL CARCINOMA ; WHITE-MATTER ; TRACTOGRAPHY ; IRRADIATION ; STATISTICS ; DAMAGE
Indexed BySCI
Language英语
Funding ProjectKey R&D Program of Anhui Province[201904a07020104] ; Natural Science Fund of Anhui Province[2008085MC69] ; General scientific research project of Anhui Provincial Health Commission[AHWJ2021b150] ; Natural Science Fund of Hefei City[2021033] ; Collaborative Innovation Program of Hefei Science Center, CAS[2020HSC-CIP001] ; Collaborative Innovation Program of Hefei Science Center, CAS[2021HSC-CIP013] ; Anhui Province Key Laboratory of Medical Physics and Technology[LMPT201904] ; John S Dunn Research Foundation ; WF Chao Foundation
Funding OrganizationKey R&D Program of Anhui Province ; Natural Science Fund of Anhui Province ; General scientific research project of Anhui Provincial Health Commission ; Natural Science Fund of Hefei City ; Collaborative Innovation Program of Hefei Science Center, CAS ; Anhui Province Key Laboratory of Medical Physics and Technology ; John S Dunn Research Foundation ; WF Chao Foundation
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000724835200001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/126817
Collection中国科学院合肥物质科学研究院
Corresponding AuthorYang, Li-Zhuang; Li, Hai
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol, Hefei, Peoples R China
2.Univ Sci & Technol China, Hefei, Peoples R China
3.Chinese Acad Sci, Hefei Canc Hosp, Hefei, Peoples R China
4.Univ Sci & Technol China, Ctr Biomed Engn, Dept Elect Sci & Technol, Hefei, Peoples R China
5.Anhui Agr Univ, Sch Sci, Hefei, Peoples R China
6.Houston Methodist Canc Ctr, Dept Syst Med & Bioengn, Houston, TX USA
7.Cornell Univ, Weill Cornell Med Coll, Dept Radiol & Neurosci, Houston, TX USA
Recommended Citation
GB/T 7714
Liu, Jin,Wang, Wenjuan,Zhou, Yanfei,et al. Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2021.
APA Liu, Jin.,Wang, Wenjuan.,Zhou, Yanfei.,Gan, Chen.,Wang, Tengfei.,...&Li, Hai.(2021).Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy.JOURNAL OF MAGNETIC RESONANCE IMAGING.
MLA Liu, Jin,et al."Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy".JOURNAL OF MAGNETIC RESONANCE IMAGING (2021).
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