A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors

doi:10.21037/tlcr-21-899

HFCAS OpenIR

	A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors
	Xu, Xiaoling 1,2; Wang, Ding 3; Chen, Wei 2; Li, Na 2,3; Suwinski, Rafal 4; Rossi, Antonio 5; Rosell, Rafael 6; Zhong, Jianxiang 7; Fan, Yun 2,3,8
	2021-12-14
发表期刊	TRANSLATIONAL LUNG CANCER RESEARCH
ISSN	2218-6751
通讯作者	Zhong, Jianxiang(jzhong85109@hotmail.com) ; Fan, Yun(fanyun1218@163.com)
摘要	Background: The primary aim of this study was to investigate the prognostic value of peripheral blood lymphocyte subsets in non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Methods: From 2018 to 2019, 82 patients diagnosed with stage IIIB-IV NSCLC at Zhejiang Cancer Hospital were recruited for this study. Peripheral blood lymphocyte subsets of NSCLC patients were analyzed using flow cytometry before and after ICI treatment. The relationship between the percentage of peripheral blood lymphocyte subsets, clinicopathological features, progression-free survival (PFS), and overall survival (OS) was identified by correlation heat map, Kaplan-Meier curve, log-rank test, and Cox regression analysis. Results: The CD4/CD8 ratio and the percentage of B cells was decreased after ICI treatment. Furthermore, the percentage of CD3(+) T cells, natural killer (NK) cells, and natural killer T (NKT) cells before ICI treatment was associated with brain metastases, the proportion of CD3(+)CD4(+) T cells before ICI treatment was related to epidermal growth factor receptor (EGFR) status, the CD4/CD8 ratio before ICI treatment was correlated to pathology, the ratio of B cells before ICI treatment was related to therapeutic regimen, and the percentage of NKT cells before ICI treatment was associated with use of radiotherapy. Furthermore, univariate survival analysis revealed that low percentage of B cells forecasted a poor OS for NSCLC patients with ICI treatment. In addition, the nomogram developed by percentages of peripheral blood lymphocyte subsets could determine survival probability and survival time of NSCLC patients with immunotherapy. Conclusions: ICI treatment induced changes in the percentage of peripheral blood lymphocyte subsets, which had prognostic value for brain metastases, radiotherapy, EGFR status, pathology, and therapeutic regimen, along with prognostic value, for NSCLC patients treated with ICIs.
关键词	Immune checkpoint inhibitor (ICI) non-small cell lung cancer (NSCLC) peripheral blood lymphocyte subsets
DOI	10.21037/tlcr-21-899
关键词[WOS]	IMMUNOTHERAPY ; NSCLC
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81802995] ; Zhejiang Province Public Welfare Funds[LGF19H280004]
项目资助者	National Natural Science Foundation of China ; Zhejiang Province Public Welfare Funds
WOS研究方向	Oncology ; Respiratory System
WOS类目	Oncology ; Respiratory System
WOS记录号	WOS:000734092800001
出版者	AME PUBL CO
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/127188
专题	中国科学院合肥物质科学研究院
通讯作者	Zhong, Jianxiang; Fan, Yun
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Canc Hosp, 1 East Banshan Rd, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, 1 East Banshan Rd, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Med Coll 2, 548 Binwen Rd, Hangzhou 310053, Peoples R China 4.Maria Sklodowska Curie Natl Res Inst Oncol, Radiotherapy & Chemotherapy Clin & Teaching Hosp, Gliwice, Poland 5.IQVIA, Oncol Ctr Excellence, Therapeut Sci & Strategy Unit, Milan, Italy 6.Germans Trias & Pujol Hlth Sci Inst & Hosp IGTP, Canc Biol & Precis Med Unit, Barcelona, Spain 7.Southeast Univ, Sch Life Sci & Technol, 2 Sipailou, Nanjing, Peoples R China 8.Univ Chinese Acad Sci, Zhejiang Key Lab Diag & Treatment Technol Thorac, Inst Canc Res & Basic Med Sci, Canc Hosp,Chinese Acad Sci,Zhejiang Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiaoling,Wang, Ding,Chen, Wei,et al. A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors[J]. TRANSLATIONAL LUNG CANCER RESEARCH,2021.
APA	Xu, Xiaoling.,Wang, Ding.,Chen, Wei.,Li, Na.,Suwinski, Rafal.,...&Fan, Yun.(2021).A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors.TRANSLATIONAL LUNG CANCER RESEARCH.
MLA	Xu, Xiaoling,et al."A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors".TRANSLATIONAL LUNG CANCER RESEARCH (2021).