Knowledge Management System of Hefei Institute of Physical Science，CAS
| Mechanisms of non-coding RNA-modulated alternative splicing in cancer | |
Wang, Xiaolin1,2,3,4 ; Hua, Jinghan1,2; Li, Jingxin2; Zhang, Jiahui1,2; Dzakah, Emmanuel Enoch5; Cao, Guozhen1,2; Lin, Wenchu1,3,4
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| 2022-12-31 | |
| Source Publication | RNA BIOLOGY
 |
| ISSN | 1547-6286 |
| Corresponding Author | Lin, Wenchu(wenchu@hmfl.ac.cn) |
| Abstract | Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis. |
| Keyword | Alternative splicing splicing factor cancer progression miRNA lncRNA circRNA |
| DOI | 10.1080/15476286.2022.2062846 |
| WOS Keyword | CIRCULAR RNAS ; MESSENGER-RNA ; MYC ; IDENTIFICATION ; TRANSCRIPTION ; COMPLEXITY ; LANDSCAPE ; HALLMARKS ; INSIGHTS ; MALAT1 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | High Magnetic Field Laboratory of Anhui Province |
| Funding Organization | High Magnetic Field Laboratory of Anhui Province |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000782921000001 |
| Publisher | TAYLOR & FRANCIS INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.hfcas.ac.cn:8080/handle/334002/128666 |
| Collection | 中国科学院合肥物质科学研究院 |
| Corresponding Author | Lin, Wenchu |
| Affiliation | 1.Chinese Acad Sci, Hefei Inst Phys Sci Hips, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, HIPS, Hefei, Anhui, Peoples R China 4.High Magnet Field Lab Anhui Prov, Hefei, Anhui, Peoples R China 5.Univ Cape Coast, Coll Agr & Nat Sci, Sch Biol Sci, Dept Mol Biol & Biotechnol, Cape Coast, Ghana |
| Recommended Citation GB/T 7714 | Wang, Xiaolin,Hua, Jinghan,Li, Jingxin,et al. Mechanisms of non-coding RNA-modulated alternative splicing in cancer[J]. RNA BIOLOGY,2022,19. |
| APA | Wang, Xiaolin.,Hua, Jinghan.,Li, Jingxin.,Zhang, Jiahui.,Dzakah, Emmanuel Enoch.,...&Lin, Wenchu.(2022).Mechanisms of non-coding RNA-modulated alternative splicing in cancer.RNA BIOLOGY,19. |
| MLA | Wang, Xiaolin,et al."Mechanisms of non-coding RNA-modulated alternative splicing in cancer".RNA BIOLOGY 19(2022). |
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