HFCAS OpenIR
Mechanisms of non-coding RNA-modulated alternative splicing in cancer
Wang, Xiaolin1,2,3,4; Hua, Jinghan1,2; Li, Jingxin2; Zhang, Jiahui1,2; Dzakah, Emmanuel Enoch5; Cao, Guozhen1,2; Lin, Wenchu1,3,4
2022-12-31
Source PublicationRNA BIOLOGY
ISSN1547-6286
Corresponding AuthorLin, Wenchu(wenchu@hmfl.ac.cn)
AbstractAlternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis.
KeywordAlternative splicing splicing factor cancer progression miRNA lncRNA circRNA
DOI10.1080/15476286.2022.2062846
WOS KeywordCIRCULAR RNAS ; MESSENGER-RNA ; MYC ; IDENTIFICATION ; TRANSCRIPTION ; COMPLEXITY ; LANDSCAPE ; HALLMARKS ; INSIGHTS ; MALAT1
Indexed BySCI
Language英语
Funding ProjectHigh Magnetic Field Laboratory of Anhui Province
Funding OrganizationHigh Magnetic Field Laboratory of Anhui Province
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000782921000001
PublisherTAYLOR & FRANCIS INC
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/128666
Collection中国科学院合肥物质科学研究院
Corresponding AuthorLin, Wenchu
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci Hips, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, HIPS, Hefei, Anhui, Peoples R China
4.High Magnet Field Lab Anhui Prov, Hefei, Anhui, Peoples R China
5.Univ Cape Coast, Coll Agr & Nat Sci, Sch Biol Sci, Dept Mol Biol & Biotechnol, Cape Coast, Ghana
Recommended Citation
GB/T 7714
Wang, Xiaolin,Hua, Jinghan,Li, Jingxin,et al. Mechanisms of non-coding RNA-modulated alternative splicing in cancer[J]. RNA BIOLOGY,2022,19.
APA Wang, Xiaolin.,Hua, Jinghan.,Li, Jingxin.,Zhang, Jiahui.,Dzakah, Emmanuel Enoch.,...&Lin, Wenchu.(2022).Mechanisms of non-coding RNA-modulated alternative splicing in cancer.RNA BIOLOGY,19.
MLA Wang, Xiaolin,et al."Mechanisms of non-coding RNA-modulated alternative splicing in cancer".RNA BIOLOGY 19(2022).
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