Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma

doi:10.1097/MD.0000000000030278

HFCAS OpenIR

	Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma
	Zou, Yang-Fan 1,2; Zhang, Shu-Yuan 1,2; Li, Li-Weng 1,2; Jing, Kai 1,2; Xia, Liang 1,2; Sun, Cai-Xing 1,2; Wu, Bin1,2
	2022-09-16
发表期刊	MEDICINE
ISSN	0025-7974
通讯作者	Wu, Bin(wubintop@163.com)
摘要	Background: Adamantinomatous craniopharyngioma (ACP) is a subtype of craniopharyngioma, a neoplastic disease with a benign pathological phenotype but a poor prognosis in the sellar region. The disease has been considered the most common congenital tumor in the skull. Therefore, this article aims to identify hub genes that might serve as genetic markers of diagnosis, treatment, and prognosis of ACP. Methods: The procedure of this research includes the acquisition of public data, identification and functional annotation of differentially expressed genes (DEGs), construction and analysis of protein-protein interaction network, and the mining and analysis of hub genes by Spearman-rho test, multivariable linear regression, and receiver operator characteristic curve analysis. Quantitative real-time polymerase chain reaction was used to detect the level of mRNA of relative genes. Results: Among 2 datasets, a total of 703 DEGs were identified, mainly enriched in chemical synaptic transmission, cell adhesion, odontogenesis of the dentin-containing tooth, cell junction, extracellular region, extracellular space, structural molecule activity, and structural constituent of cytoskeleton. The protein-protein interaction network was composed of 4379 edges and 589 nodes. Its significant module had 10 hub genes, and SYN1, SYP, and GRIA2 were significantly down-regulated with ACP. Conclusion: In a word, we find out the DEGs between ACP patients and standard samples, which are likely to play an essential role in the development of ACP. At the same time, these DEGs are of great value in tumors' diagnosis and targeted therapy and could even be mined as biological molecular targets for diagnosing and treating ACP patients.
关键词	adamantinomatous craniopharyngioma biological information technology biomarker differentially expressed genes
DOI	10.1097/MD.0000000000030278
关键词[WOS]	SYNAPSIN-I ; EXPRESSION ; TUMOR ; GRIA2 ; PHOSPHORYLATION ; IDENTIFICATION ; MATURATION ; PLASTICITY ; CHILDHOOD ; BINDING
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81502147] ; Zhejiang Medical Science and Technology Project[2017KY260] ; Zhejiang Medical Science and Technology Project[2018KY292] ; Zhejiang Medical Science and Technology Project[2019RC127] ; Zhejiang Medical Science and Technology Project[2018KY291] ; Chinese Medicine Science and Technology Plan of Zhejiang Province[2016ZA039] ; Youth Scientific Innovation Foundation of Zhejiang Cancer Hospital[QN201402] ; Youth Scientific Innovation Foundation of Zhejiang Cancer Hospital[QN201902]
项目资助者	National Natural Science Foundation of China ; Zhejiang Medical Science and Technology Project ; Chinese Medicine Science and Technology Plan of Zhejiang Province ; Youth Scientific Innovation Foundation of Zhejiang Cancer Hospital
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:000855119700079
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/128965
专题	中国科学院合肥物质科学研究院
通讯作者	Wu, Bin
作者单位	1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Univ Chinese Acad Sci,Dept Neurosurg,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Zou, Yang-Fan,Zhang, Shu-Yuan,Li, Li-Weng,et al. Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma[J]. MEDICINE,2022,101.
APA	Zou, Yang-Fan.,Zhang, Shu-Yuan.,Li, Li-Weng.,Jing, Kai.,Xia, Liang.,...&Wu, Bin.(2022).Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma.MEDICINE,101.
MLA	Zou, Yang-Fan,et al."Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma".MEDICINE 101(2022).