HFCAS OpenIR
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
Xu, Chunwei1,2; Si, Lu3; Wang, Wenxian4; Li, Ziming5; Song, Zhengbo4; Wang, Qian6; Liu, Aijun7; Yu, Jinpu8; Fang, Wenfeng9; Zhong, Wenzhao10; Wang, Zhijie11; Zhang, Yongchang12; Liu, Jingjing13; Zhang, Shirong14; Cai, Xiuyu15; Liu, Anwen16; Li, Wen17; Zhan, Ping2; Liu, Hongbing2; Lv, Tangfeng2; Miao, Liyun18; Min, Lingfeng19; Chen, Yu20,21; Yuan, Jingping22; Wang, Feng23; Jiang, Zhansheng24; Lin, Gen20,21; Pu, Xingxiang25; Lin, Rongbo20,21; Liu, Weifeng26; Rao, Chuangzhou27; Lv, Dongqing28; Yu, Zongyang29; Lei, Lei4; Li, Xiaoyan30; Tang, Chuanhao31; Zhou, Chengzhi32; Zhang, Junping33; Xue, Junli34; Guo, Hui35; Chu, Qian36; Meng, Rui37; Wu, Jingxun38; Zhang, Rui39; Hu, Xiao40; Zhou, Jin41; Zhu, Zhengfei42; Li, Yongheng43; Qiu, Hong36; Xia, Fan42; Lu, Yuanyuan44,45,46; Chen, Xiaofeng47,48; Ge, Rui49; Dai, Enyong50; Han, Yu51; Pan, Weiwei52; Luo, Jiancheng53; Jia, Hongtao53; Dong, Xiaowei54; Pang, Fei54; Wang, Kai54; Wang, Liping55; Zhu, Youcai56; Xie, Yanru57; Lin, Xinqin32; Cai, Jing16; Wei, Jia58; Lan, Fen17; Feng, Huijing33; Wang, Lin59; Du, Yingying60; Yao, Wang61; Shi, Xuefei62; Niu, Xiaomin5; Yuan, Dongmei2; Yao, Yanwen2; Huang, Jianhui57; Zhang, Yinbin63; Sun, Pingli64; Wang, Hong65; Ye, Mingxiang2; Wang, Dong2; Wang, Zhaofeng2; Wan, Bing66; Lv, Donglai67; Wei, Qing4; Kang, Jin10; Zhang, Jiatao10; Zhang, Chao11; Yu, Genhua68; Ou, Juanjuan69,70; Shi, Lin71; Li, Zhongwu72; Liu, Zhefeng65; Liu, Jing73; Yang, Nong12; Wu, Lin25; Wang, Huijuan74; Jin, Gu75; Yang, Liu76; Wang, Guansong77; Fang, Meiyu4; Fang, Yong78; Li, Yuan79; Wang, Xiaojia4; Zhang, Yiping4; Ma, Shenglin80; Wang, Biyun81; Zhang, Xiaotian82; Song, Yong2; Lu, Yuanzhi83
2022-09-20
Source PublicationTHORACIC CANCER
ISSN1759-7706
Corresponding AuthorZhang, Xiaotian(zhangxiaotianmed@163.com) ; Song, Yong(yong.song@nju.edu.cn) ; Lu, Yuanzhi(yuanzhi.lu@jnu.edu.cn)
AbstractGene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the first "tumor agnostic" drugs approved for pan-cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy for many types of cancer. At the same time, several second-generation drugs designed to overcome first-generation drug resistance are undergoing clinical development. Due to the rarity of NTRK gene fusions in common cancer types and technical issues regarding the complexity of fusion patterns, effectively screening patients for TRK inhibitor treatment in routine clinical practice is challenging. Different detection methods including immunohistochemistry, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and (DNA and/or RNA-based) next-generation sequencing have pros and cons. As such, recommending suitable tests for individual patients and ensuring the quality of tests is essential. Moreover, at present, there is a lack of systematic review for the clinical efficacy and development status of first- and second-generation TRK inhibitors. To resolve the above issues, our expert group has reached a consensus regarding the diagnosis and treatment of NTRK gene fusion solid tumors, aiming to standardize clinical practice with the goal of benefiting patients with NTRK gene fusions treated with TRK inhibitors.
Keywordfusion precision medicine solid tumor targeted therapy tyrosine receptor kinase
DOI10.1111/1759-7714.14644
WOS KeywordINFANTILE FIBROSARCOMA ; MESOBLASTIC NEPHROMA ; MOLECULAR-DETECTION ; ANCHORED MULTIPLEX ; KINASE ; EXPRESSION ; MUTATIONS ; FAMILY ; INHIBITION ; RECEPTORS
Indexed BySCI
Language英语
WOS Research AreaOncology ; Respiratory System
WOS SubjectOncology ; Respiratory System
WOS IDWOS:000855706000001
PublisherWILEY
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/128991
Collection中国科学院合肥物质科学研究院
Corresponding AuthorZhang, Xiaotian; Song, Yong; Lu, Yuanzhi
Affiliation1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China
2.Nanjing Univ, Affiliated Jinling Hosp, Dept Resp Med, Med Sch, Nanjing 210002, Jiangsu, Peoples R China
3.Peking Univ Canc Hosp & Inst, Dept Melanoma & Sarcoma, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing, Peoples R China
4.Chinese Acad Sci Univ Canc Hosp, Dept Chemotherapy, Zhejiang Canc Hosp, Hangzhou, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Shanghai Lung Canc Ctr, Shanghai, Peoples R China
6.Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Resp Med, Affiliated Hosp, Nanjing, Peoples R China
7.Peoples Liberat Army Gen Hosp, Dept Pathol, Med Ctr 7, Beijing, Peoples R China
8.Tianjin Med Univ Canc Inst & Hosp, Canc Mol Diagnost Core, Tianjin, Peoples R China
9.Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Med Oncol, State Key Lab Oncol South China, Guangzhou, Peoples R China
10.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Sch Med,Guangdong Prov Lab Translat Med Lung Canc, Guangdong Lung Canc Inst, Guangzhou, Peoples R China
11.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Dept Med Oncol, State Key Lab Mol Oncol, Beijing, Peoples R China
12.Cent South Univ, Lung Canc & Gastrointestinal Unit, Dept Med Oncol,Xiangya Sch Med, Hunan Canc Hosp,Affiliated Canc Hosp, Changsha, Peoples R China
13.Jilin Canc Hosp, Dept Thorac Canc, Changchun, Peoples R China
14.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Translat Med Res Ctr, Canc Ctr,Sch Med,Key Lab Clin Canc Pharmacol & To, Hangzhou, Peoples R China
15.Sun Yet Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept VIP Inpatient, State Key Lab Oncol South China, Guangzhou, Peoples R China
16.Nanchang Univ, Dept Oncol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China
17.Zhejiang Univ, Key Lab Resp Divas Zhejiang Prov, Canc Ctr,Sch Med, Dept Resp & Crit Care Med,Affiliated Hosp 2, Hangzhou, Peoples R China
18.Nanjing Univ, Dept Resp Med, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Peoples R China
19.Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Dept Resp Med, Clin Med Sch, Yangzhou, Jiangsu, Peoples R China
20.Fujian Med Univ Canc Hosp, Dept Med Oncol, Fuzhou, Peoples R China
21.Fujian Canc Hosp, Fuzhou, Peoples R China
22.Wuhan Univ, Dept Pathol, Renmin Hosp, Wuhan, Peoples R China
23.Nanjing Univ, Affiliated Jinling Hosp, Canc Ctr PLA, Dept Internal Med,Med Sch,Qinhuai Med Area, Nanjing, Peoples R China
24.Tianjin Med Univ Canc Inst & Hosp, Dept Integrat Oncol, Tianjin, Peoples R China
25.Cent South Univ, Lung Canc & Hunan Canc Hosp, Dept Med Oncol, Affiliated Canc Hosp,Xiangya Sch Med, Changsha, Peoples R China
26.Peking Univ, Beijing Ji Shui Tan Hosp, Dept Orthopaed Oncol Surg, Beijing, Peoples R China
27.Univ Chinese Acad Sci, Hwamei Hosp, Dept Radiotherapy & Chemotherapy, Ningbo, Peoples R China
28.Wenzhou Med Univ, Dept Pulm Med, Taizhou Hosp, Taizhou, Peoples R China
29.Fujian Med Univ, Fuzhou Gen Hosp, Dept Resp Med, Hosp 900,Joint Logist Team, Fuzhou, Peoples R China
30.Capital Med Univ, Beijing Tiantan Hosp, Dept Oncol, Beijing, Peoples R China
31.Peking Univ Int Hosp, Dept Med Oncol, Beijing, Peoples R China
32.Guangzhou Med Univ, State Key Lab Resp Divas, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, Guangzhou, Peoples R China
33.Shanxi Acad Med Sci, Shanxi Bethune Hosp, Dept Thorac Oncol, Taiyuan, Peoples R China
34.Tongji Univ, Shanghai East Hosp, Sch Med, Dept Oncol, Shanghai, Peoples R China
35.Xisn Jiaotong Univ, Dept Med Oncol, Affiliated Hosp 1, Xian, Peoples R China
36.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Oncol, Tongji Hosp, Wuhan, Peoples R China
37.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan, Peoples R China
38.Xiamen Univ, Affiliated Hosp Med 1, Dept Med Oncol, Xiamen, Peoples R China
39.China Med Univ, Dept Med Oncol, Canc Hosp, Shenyang, Peoples R China
40.Univ Chinese Acad Sci, Zhejiang Key Lab Radiat Oncol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China
41.Univ Elect Sci & Technol, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med, Chengdu, Peoples R China
42.Fudan Univ, Dept Radiat Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China
43.Peking Univ Canc Hosp & Inst, Dept Radiat Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China
44.Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Peoples R China
45.Fourth Mil Med Univ, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Peoples R China
46.Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian, Peoples R China
47.Jiangsu Prov Hosp, Dept Oncol, Nanjing, Peoples R China
48.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China
49.Fudan Univ, Dept Gen Surg, Huadong Hosp, Shanghai, Peoples R China
50.Jilin Univ, Dept Oncol & Hematol, China Japan Union Hosp, Changchun, Peoples R China
51.Harbin Med Univ Canc Hosp, Dept Gastrointestinal Oncol, Harbin, Peoples R China
52.Jiaxing Univ, Coll Med, Dept Cell Biol, Jiaxing, Peoples R China
53.Aiyi Technol Co Ltd, Beijing, Peoples R China
54.Shanghai OrigiMed Co Ltd, Dept Pathol, Shanghai, Peoples R China
55.Baotou Canc Hosp, Dept Oncol, Baotou, Peoples R China
56.Jiaxing Univ, Zhejiang Rongjun Hosp, Dept Thorac Dis, Diag & Treatment Ctr,Affiliated Hosp 3, Jiaxing, Peoples R China
57.Lishui Municipal Cent Hosp, Dept Oncol, Lishui, Peoples R China
58.Nanjing Univ, Dept Comprehens Canc Ctr, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Peoples R China
59.Shanxi Bethune Hosp, Shanxi Acad Med Sci, Dept Pathol, Taiyuan, Peoples R China
60.Anhui Med Univ, Dept Oncol, Affiliated Hosp 1, Hefei, Peoples R China
61.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, Guangzhou, Peoples R China
62.Zhejiang Univ, Huzhou Hosp, Dept Resp Med, Sch Med, Huzhou, Peoples R China
63.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, Med Coll, Xian, Peoples R China
64.Second Hosp Jilin Univ, Dept Pathol, Changchun, Peoples R China
65.Peoples Liberat Army Gen Hosp, Dept Oncol, Med Ctr 5, Beijing, Peoples R China
66.Nanjing Med Univ, Dept Resp Med, Affiliated Jiangning Hosp, Nanjing, Peoples R China
67.901 Hosp Joint Logist Support Force People Libera, Dept Clin Oncol, Hefei, Peoples R China
68.Zhebei Mingzhou Hosp, Dept Radiat Oncol, Huzhou, Peoples R China
69.Third Mil Med Univ Army Med Univ, Southwest Hosp, Dept Oncol, Chongqing, Peoples R China
70.Third Mil Med Univ Army Med Univ, Southwest Hosp, Southwest Canc Ctr, Chongqing, Peoples R China
71.Fudan Univ, Zhongshan Hosp, Dept Resp Med, Shanghai, Peoples R China
72.Peking Univ Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing, Peoples R China
73.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Oncol, Sch Med, Shanghai, Peoples R China
74.Zhengzhou Univ, Henan Canc Hosp, Dept Internal Med, Affiliated Canc Hosp, Zhengzhou, Peoples R China
75.Chinese Acad Sci Univ Canc Hosp, Dept Bone & Soft Tissue Surg, Zhejiang Canc Hosp, Hangzhou, Peoples R China
76.Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Tumor Mol Diag & Individualized Med Zheji, Hangzhou, Peoples R China
77.Third Mil Med Univ, Xinqiao Hosp, Inst Resp Dis, Chongqing, Peoples R China
78.Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou, Peoples R China
79.Fudan Univ, Dept Pathol, Shanghai Canc Ctr, Shanghai, Peoples R China
80.Zhejiang Univ, Affiliated Hangzhou Canc Hosp, Canc Ctr,Res Zhejiang Prov, Dept Oncol,Sch Med,Key Lab Clin Canc Pharmacol &, Hangzhou, Peoples R China
81.Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll,Dept Oncol, Dept Breast Canc & Urol Med Oncol, Shanghai, Peoples R China
82.Peking Univ Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing 100142, Peoples R China
83.Jinan Univ, Dept Clin Pathol, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Xu, Chunwei,Si, Lu,Wang, Wenxian,et al. Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China[J]. THORACIC CANCER,2022.
APA Xu, Chunwei.,Si, Lu.,Wang, Wenxian.,Li, Ziming.,Song, Zhengbo.,...&Lu, Yuanzhi.(2022).Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China.THORACIC CANCER.
MLA Xu, Chunwei,et al."Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China".THORACIC CANCER (2022).
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