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| Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China | |
Xu, Chunwei1,2; Si, Lu3; Wang, Wenxian4; Li, Ziming5; Song, Zhengbo4; Wang, Qian6; Liu, Aijun7; Yu, Jinpu8; Fang, Wenfeng9; Zhong, Wenzhao10; Wang, Zhijie11; Zhang, Yongchang12; Liu, Jingjing13; Zhang, Shirong14; Cai, Xiuyu15; Liu, Anwen16; Li, Wen17; Zhan, Ping2; Liu, Hongbing2; Lv, Tangfeng2; Miao, Liyun18; Min, Lingfeng19; Chen, Yu20,21 ; Yuan, Jingping22; Wang, Feng23; Jiang, Zhansheng24; Lin, Gen20,21; Pu, Xingxiang25; Lin, Rongbo20,21; Liu, Weifeng26; Rao, Chuangzhou27; Lv, Dongqing28; Yu, Zongyang29; Lei, Lei4; Li, Xiaoyan30; Tang, Chuanhao31; Zhou, Chengzhi32; Zhang, Junping33; Xue, Junli34; Guo, Hui35; Chu, Qian36; Meng, Rui37; Wu, Jingxun38; Zhang, Rui39; Hu, Xiao40; Zhou, Jin41; Zhu, Zhengfei42; Li, Yongheng43; Qiu, Hong36; Xia, Fan42; Lu, Yuanyuan44,45,46; Chen, Xiaofeng47,48; Ge, Rui49; Dai, Enyong50; Han, Yu51; Pan, Weiwei52; Luo, Jiancheng53; Jia, Hongtao53; Dong, Xiaowei54; Pang, Fei54; Wang, Kai54; Wang, Liping55; Zhu, Youcai56; Xie, Yanru57; Lin, Xinqin32; Cai, Jing16; Wei, Jia58; Lan, Fen17; Feng, Huijing33; Wang, Lin59; Du, Yingying60; Yao, Wang61; Shi, Xuefei62; Niu, Xiaomin5; Yuan, Dongmei2; Yao, Yanwen2; Huang, Jianhui57; Zhang, Yinbin63; Sun, Pingli64; Wang, Hong65; Ye, Mingxiang2; Wang, Dong2; Wang, Zhaofeng2; Wan, Bing66; Lv, Donglai67; Wei, Qing4; Kang, Jin10; Zhang, Jiatao10; Zhang, Chao11; Yu, Genhua68; Ou, Juanjuan69,70; Shi, Lin71; Li, Zhongwu72; Liu, Zhefeng65; Liu, Jing73; Yang, Nong12; Wu, Lin25; Wang, Huijuan74; Jin, Gu75; Yang, Liu76; Wang, Guansong77; Fang, Meiyu4; Fang, Yong78; Li, Yuan79; Wang, Xiaojia4; Zhang, Yiping4; Ma, Shenglin80; Wang, Biyun81; Zhang, Xiaotian82; Song, Yong2; Lu, Yuanzhi83
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| 2022-09-20 | |
| Source Publication | THORACIC CANCER
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| ISSN | 1759-7706 |
| Corresponding Author | Zhang, Xiaotian(zhangxiaotianmed@163.com) ; Song, Yong(yong.song@nju.edu.cn) ; Lu, Yuanzhi(yuanzhi.lu@jnu.edu.cn) |
| Abstract | Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the first "tumor agnostic" drugs approved for pan-cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy for many types of cancer. At the same time, several second-generation drugs designed to overcome first-generation drug resistance are undergoing clinical development. Due to the rarity of NTRK gene fusions in common cancer types and technical issues regarding the complexity of fusion patterns, effectively screening patients for TRK inhibitor treatment in routine clinical practice is challenging. Different detection methods including immunohistochemistry, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and (DNA and/or RNA-based) next-generation sequencing have pros and cons. As such, recommending suitable tests for individual patients and ensuring the quality of tests is essential. Moreover, at present, there is a lack of systematic review for the clinical efficacy and development status of first- and second-generation TRK inhibitors. To resolve the above issues, our expert group has reached a consensus regarding the diagnosis and treatment of NTRK gene fusion solid tumors, aiming to standardize clinical practice with the goal of benefiting patients with NTRK gene fusions treated with TRK inhibitors. |
| Keyword | fusion precision medicine solid tumor targeted therapy tyrosine receptor kinase |
| DOI | 10.1111/1759-7714.14644 |
| WOS Keyword | INFANTILE FIBROSARCOMA ; MESOBLASTIC NEPHROMA ; MOLECULAR-DETECTION ; ANCHORED MULTIPLEX ; KINASE ; EXPRESSION ; MUTATIONS ; FAMILY ; INHIBITION ; RECEPTORS |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Oncology ; Respiratory System |
| WOS Subject | Oncology ; Respiratory System |
| WOS ID | WOS:000855706000001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.hfcas.ac.cn:8080/handle/334002/128991 |
| Collection | 中国科学院合肥物质科学研究院 |
| Corresponding Author | Zhang, Xiaotian; Song, Yong; Lu, Yuanzhi |
| Affiliation | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 2.Nanjing Univ, Affiliated Jinling Hosp, Dept Resp Med, Med Sch, Nanjing 210002, Jiangsu, Peoples R China 3.Peking Univ Canc Hosp & Inst, Dept Melanoma & Sarcoma, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing, Peoples R China 4.Chinese Acad Sci Univ Canc Hosp, Dept Chemotherapy, Zhejiang Canc Hosp, Hangzhou, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Shanghai Lung Canc Ctr, Shanghai, Peoples R China 6.Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Resp Med, Affiliated Hosp, Nanjing, Peoples R China 7.Peoples Liberat Army Gen Hosp, Dept Pathol, Med Ctr 7, Beijing, Peoples R China 8.Tianjin Med Univ Canc Inst & Hosp, Canc Mol Diagnost Core, Tianjin, Peoples R China 9.Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Med Oncol, State Key Lab Oncol South China, Guangzhou, Peoples R China 10.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Sch Med,Guangdong Prov Lab Translat Med Lung Canc, Guangdong Lung Canc Inst, Guangzhou, Peoples R China 11.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Dept Med Oncol, State Key Lab Mol Oncol, Beijing, Peoples R China 12.Cent South Univ, Lung Canc & Gastrointestinal Unit, Dept Med Oncol,Xiangya Sch Med, Hunan Canc Hosp,Affiliated Canc Hosp, Changsha, Peoples R China 13.Jilin Canc Hosp, Dept Thorac Canc, Changchun, Peoples R China 14.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Translat Med Res Ctr, Canc Ctr,Sch Med,Key Lab Clin Canc Pharmacol & To, Hangzhou, Peoples R China 15.Sun Yet Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept VIP Inpatient, State Key Lab Oncol South China, Guangzhou, Peoples R China 16.Nanchang Univ, Dept Oncol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China 17.Zhejiang Univ, Key Lab Resp Divas Zhejiang Prov, Canc Ctr,Sch Med, Dept Resp & Crit Care Med,Affiliated Hosp 2, Hangzhou, Peoples R China 18.Nanjing Univ, Dept Resp Med, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Peoples R China 19.Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Dept Resp Med, Clin Med Sch, Yangzhou, Jiangsu, Peoples R China 20.Fujian Med Univ Canc Hosp, Dept Med Oncol, Fuzhou, Peoples R China 21.Fujian Canc Hosp, Fuzhou, Peoples R China 22.Wuhan Univ, Dept Pathol, Renmin Hosp, Wuhan, Peoples R China 23.Nanjing Univ, Affiliated Jinling Hosp, Canc Ctr PLA, Dept Internal Med,Med Sch,Qinhuai Med Area, Nanjing, Peoples R China 24.Tianjin Med Univ Canc Inst & Hosp, Dept Integrat Oncol, Tianjin, Peoples R China 25.Cent South Univ, Lung Canc & Hunan Canc Hosp, Dept Med Oncol, Affiliated Canc Hosp,Xiangya Sch Med, Changsha, Peoples R China 26.Peking Univ, Beijing Ji Shui Tan Hosp, Dept Orthopaed Oncol Surg, Beijing, Peoples R China 27.Univ Chinese Acad Sci, Hwamei Hosp, Dept Radiotherapy & Chemotherapy, Ningbo, Peoples R China 28.Wenzhou Med Univ, Dept Pulm Med, Taizhou Hosp, Taizhou, Peoples R China 29.Fujian Med Univ, Fuzhou Gen Hosp, Dept Resp Med, Hosp 900,Joint Logist Team, Fuzhou, Peoples R China 30.Capital Med Univ, Beijing Tiantan Hosp, Dept Oncol, Beijing, Peoples R China 31.Peking Univ Int Hosp, Dept Med Oncol, Beijing, Peoples R China 32.Guangzhou Med Univ, State Key Lab Resp Divas, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, Guangzhou, Peoples R China 33.Shanxi Acad Med Sci, Shanxi Bethune Hosp, Dept Thorac Oncol, Taiyuan, Peoples R China 34.Tongji Univ, Shanghai East Hosp, Sch Med, Dept Oncol, Shanghai, Peoples R China 35.Xisn Jiaotong Univ, Dept Med Oncol, Affiliated Hosp 1, Xian, Peoples R China 36.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Oncol, Tongji Hosp, Wuhan, Peoples R China 37.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan, Peoples R China 38.Xiamen Univ, Affiliated Hosp Med 1, Dept Med Oncol, Xiamen, Peoples R China 39.China Med Univ, Dept Med Oncol, Canc Hosp, Shenyang, Peoples R China 40.Univ Chinese Acad Sci, Zhejiang Key Lab Radiat Oncol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 41.Univ Elect Sci & Technol, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med, Chengdu, Peoples R China 42.Fudan Univ, Dept Radiat Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China 43.Peking Univ Canc Hosp & Inst, Dept Radiat Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China 44.Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Peoples R China 45.Fourth Mil Med Univ, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Peoples R China 46.Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian, Peoples R China 47.Jiangsu Prov Hosp, Dept Oncol, Nanjing, Peoples R China 48.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China 49.Fudan Univ, Dept Gen Surg, Huadong Hosp, Shanghai, Peoples R China 50.Jilin Univ, Dept Oncol & Hematol, China Japan Union Hosp, Changchun, Peoples R China 51.Harbin Med Univ Canc Hosp, Dept Gastrointestinal Oncol, Harbin, Peoples R China 52.Jiaxing Univ, Coll Med, Dept Cell Biol, Jiaxing, Peoples R China 53.Aiyi Technol Co Ltd, Beijing, Peoples R China 54.Shanghai OrigiMed Co Ltd, Dept Pathol, Shanghai, Peoples R China 55.Baotou Canc Hosp, Dept Oncol, Baotou, Peoples R China 56.Jiaxing Univ, Zhejiang Rongjun Hosp, Dept Thorac Dis, Diag & Treatment Ctr,Affiliated Hosp 3, Jiaxing, Peoples R China 57.Lishui Municipal Cent Hosp, Dept Oncol, Lishui, Peoples R China 58.Nanjing Univ, Dept Comprehens Canc Ctr, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Peoples R China 59.Shanxi Bethune Hosp, Shanxi Acad Med Sci, Dept Pathol, Taiyuan, Peoples R China 60.Anhui Med Univ, Dept Oncol, Affiliated Hosp 1, Hefei, Peoples R China 61.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, Guangzhou, Peoples R China 62.Zhejiang Univ, Huzhou Hosp, Dept Resp Med, Sch Med, Huzhou, Peoples R China 63.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, Med Coll, Xian, Peoples R China 64.Second Hosp Jilin Univ, Dept Pathol, Changchun, Peoples R China 65.Peoples Liberat Army Gen Hosp, Dept Oncol, Med Ctr 5, Beijing, Peoples R China 66.Nanjing Med Univ, Dept Resp Med, Affiliated Jiangning Hosp, Nanjing, Peoples R China 67.901 Hosp Joint Logist Support Force People Libera, Dept Clin Oncol, Hefei, Peoples R China 68.Zhebei Mingzhou Hosp, Dept Radiat Oncol, Huzhou, Peoples R China 69.Third Mil Med Univ Army Med Univ, Southwest Hosp, Dept Oncol, Chongqing, Peoples R China 70.Third Mil Med Univ Army Med Univ, Southwest Hosp, Southwest Canc Ctr, Chongqing, Peoples R China 71.Fudan Univ, Zhongshan Hosp, Dept Resp Med, Shanghai, Peoples R China 72.Peking Univ Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing, Peoples R China 73.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Oncol, Sch Med, Shanghai, Peoples R China 74.Zhengzhou Univ, Henan Canc Hosp, Dept Internal Med, Affiliated Canc Hosp, Zhengzhou, Peoples R China 75.Chinese Acad Sci Univ Canc Hosp, Dept Bone & Soft Tissue Surg, Zhejiang Canc Hosp, Hangzhou, Peoples R China 76.Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Tumor Mol Diag & Individualized Med Zheji, Hangzhou, Peoples R China 77.Third Mil Med Univ, Xinqiao Hosp, Inst Resp Dis, Chongqing, Peoples R China 78.Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou, Peoples R China 79.Fudan Univ, Dept Pathol, Shanghai Canc Ctr, Shanghai, Peoples R China 80.Zhejiang Univ, Affiliated Hangzhou Canc Hosp, Canc Ctr,Res Zhejiang Prov, Dept Oncol,Sch Med,Key Lab Clin Canc Pharmacol &, Hangzhou, Peoples R China 81.Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll,Dept Oncol, Dept Breast Canc & Urol Med Oncol, Shanghai, Peoples R China 82.Peking Univ Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing 100142, Peoples R China 83.Jinan Univ, Dept Clin Pathol, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Chunwei,Si, Lu,Wang, Wenxian,et al. Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China[J]. THORACIC CANCER,2022. |
| APA | Xu, Chunwei.,Si, Lu.,Wang, Wenxian.,Li, Ziming.,Song, Zhengbo.,...&Lu, Yuanzhi.(2022).Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China.THORACIC CANCER. |
| MLA | Xu, Chunwei,et al."Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China".THORACIC CANCER (2022). |
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