The value of ultrasound grayscale ratio in the diagnosis of papillary thyroid microcarcinomas and benign micronodules in patients with Hashimoto's thyroiditis: A two-center controlled study

doi:10.3389/fendo.2022.949847

HFCAS OpenIR

	The value of ultrasound grayscale ratio in the diagnosis of papillary thyroid microcarcinomas and benign micronodules in patients with Hashimoto's thyroiditis: A two-center controlled study
	Feng, Na 1,2; Wei, Peiying 3; Kong, Xiangkai 1,2; Xu, Jingjing 4; Yao, Jincao 1,2,5,6; Cheng, Fang 1,2; Ou, Di 1,2; Wang, Liping 1,2; Xu, Dong 1,2,5,6; Han, Zhijiang 3
	2022-08-12
发表期刊	FRONTIERS IN ENDOCRINOLOGY
ISSN	1664-2392
通讯作者	Xu, Dong(xudong@zjcc.org.cn) ; Han, Zhijiang(hzj1022@zju.edu.cn)
摘要	ObjectiveThe value of ultrasound grayscale ratio (UGSR) in the diagnosis of papillary thyroid microcarcinomas (PTMCs) and benign micronodules (BMNs) has been recognized by some authors, but studies have not examined these aspects in patients with Hashimoto's thyroiditis (HT). This retrospective study investigated the value of UGSR in the diagnosis of PTMCs and BMNs in patients with HT using data from two medical centers. MethodsUltrasound images of 428 PTMCs in 368 patients with HT and 225 BMNs in 181 patients with HT in center A were retrospectively analyzed and compared to the ultrasound images of 412 PTMCs in 324 patients with HT and 315 BMNs in 229 patients with HT in medical center B. All of the cases were surgically confirmed. The UGSR was calculated as the ratio of the grayscale value of lesions to the surrounding normal thyroid tissues. The optimal UGSR thresholds for the PTMCs and BMNs in patients with HT from the two medical centers were determined using a receiver operating characteristic (ROC) curve. Furthermore, other statistics, including the area under the curve (AUC), the optimal UGSR threshold, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of the two medical centers, were pair analyzed in this study. ResultsThe UGSR of PTMCs and BMNs in patients with HT from medical center A were 0.513 (0.442, 0.592) and 0.857 (0.677, 0.977) (Z = -15.564, p = 0), and those from medical center B were 0.514 (0.431, 0.625) and 0.917 (0.705, 1.131) (Z = -15.564, p = 0). For both medical centers A and B, the AUC, optimal UGSR threshold, sensitivity, specificity, PPV, NPV, and diagnostic accuracy of the UGSR in differentiating between PTMCs and BMNs in patients with HT were 0.870 and 0.889, 0.68 and 0.70, 0.921 and 0.898, 0.747 and 0.759, 0.874 and 0.829, 0.832 and 0.848, and 0.861 and 0.836, respectively. There were no significant differences in the UGSR for the PTMCs between patients from the two medical centers (Z = -0.815, p = 0.415), while there was a significant difference in the UGSR of the BMNs between patients from the two medical centers (Z = -3.637, p = 0). ConclusionIn the context of HT, UGSR still has high sensitivity, accuracy, and stability in differentiating between PTMCs and BMNs, making it a complementary differentiator of thyroid imaging reporting and data systems. However, due to its low specificity, a comprehensive analysis of other ultrasound signs is required.
关键词	ultrasound grayscale ratio papillary thyroid microcarcinomas nodular goiters diagnosis echogenicity Hashimoto's thyroiditis
DOI	10.3389/fendo.2022.949847
关键词[WOS]	NODULES ; CARCINOMA ; FEATURES
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Zhejiang Provincial Medical and Health Technology Project ; [82071946] ; [LSD19H180001] ; [LY20H180001] ; [LZY21F030001] ; [2022KY110] ; [2021RC024] ; [2020RC091]
项目资助者	National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Zhejiang Provincial Medical and Health Technology Project
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000879439800001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/129988
专题	中国科学院合肥物质科学研究院
通讯作者	Xu, Dong; Han, Zhijiang
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Ultrasound, Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 3.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Radiol, Sch Med, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Pathol, Canc Hosp, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Res Ctr Canc Intelligent Diag & Mol Technol, Canc Hosp, Hangzhou, Peoples R China 6.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Feng, Na,Wei, Peiying,Kong, Xiangkai,et al. The value of ultrasound grayscale ratio in the diagnosis of papillary thyroid microcarcinomas and benign micronodules in patients with Hashimoto's thyroiditis: A two-center controlled study[J]. FRONTIERS IN ENDOCRINOLOGY,2022,13.
APA	Feng, Na.,Wei, Peiying.,Kong, Xiangkai.,Xu, Jingjing.,Yao, Jincao.,...&Han, Zhijiang.(2022).The value of ultrasound grayscale ratio in the diagnosis of papillary thyroid microcarcinomas and benign micronodules in patients with Hashimoto's thyroiditis: A two-center controlled study.FRONTIERS IN ENDOCRINOLOGY,13.
MLA	Feng, Na,et al."The value of ultrasound grayscale ratio in the diagnosis of papillary thyroid microcarcinomas and benign micronodules in patients with Hashimoto's thyroiditis: A two-center controlled study".FRONTIERS IN ENDOCRINOLOGY 13(2022).