Knowledge Management System of Hefei Institute of Physical Science,CAS
The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma | |
Wang, Xiaojing1,2; Zhao, Yue3,4; Strohmer, Dorothee Franziska4; Yang, Wenjin1; Xia, Zhijia4; Yu, Cong1 | |
2022-08-30 | |
发表期刊 | FRONTIERS IN GENETICS |
通讯作者 | Xia, Zhijia(Zhijia.Xia@med.uni-muenchen.de) ; Yu, Cong(yucong18270916759@163.com) |
摘要 | Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows. MicroRNAs are short, non-coding RNAs that control cell differentiation and apoptosis by interfering with gene expression. In addition, microRNAs in HNSCC have been shown to affect the clinical behaviors of HNSCC in amazing ways. Moreover, metabolic reprogramming is a key part of cancer and is needed for cancer to turn into a tumor and grow. But it is still not clear what effect microRNAs related to fatty acid metabolism have on the prognosis of HNSCC patients. We downloaded the data of HNSCC patients from the TCGA database and obtained the genes associated with fatty acid metabolism according to the GSEA database. Then, the microRNAs associated with fatty acid metabolism genes were matched. Finally, fatty acid metabolism gene associated microRNAs for calculating risk scores and then building multifactorial Cox regression models in patients with HNSCC. Heatmap analysis showed that microRNAs involved in fatty acid metabolism were significantly different in HNSCC patients than in healthy controls. A total of 27 microRNAs associated with fatty acid metabolism were screened by univariate Cox analysis (p < 0.05). Using lasso regression, 18 microRNAs substantially linked with the prognosis of HNSCC patients were identified and included in risk scores. The ROC curves demonstrate that risk scores derived from microRNAs involved in fatty acid metabolism can accurately predict the prognosis of HNSCC patients at 1, 3, and 5 years. Moreover, we discovered that 11 microRNAs included in the risk score properly distinguished the prognosis of HNSCC patients. This paper indicated that microRNAs involved with fatty acid metabolism are strongly linked to the prognosis of HNSCC patients. It also indicated that reprogramming of fatty acid metabolism in tumor tissues may play an important role in HNSCC cancer. |
关键词 | fatty acid metabolism MicroRNAs head and neck squamous cell carcinoma prognostic risk score |
DOI | 10.3389/fgene.2022.983672 |
关键词[WOS] | TUMOR MICROENVIRONMENT ; INHIBITION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Pudong Health Commission of Shanghai ; [PW2020A-14] |
项目资助者 | Pudong Health Commission of Shanghai |
WOS研究方向 | Genetics & Heredity |
WOS类目 | Genetics & Heredity |
WOS记录号 | WOS:000883142400001 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/130111 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Xia, Zhijia; Yu, Cong |
作者单位 | 1.Shanghai Pudong New Area Peoples Hosp, Dept Neurosurg, Shanghai, Peoples R China 2.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Breast Surg, Canc Hosp, Hangzhou, Peoples R China 4.Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, Munich, Germany |
推荐引用方式 GB/T 7714 | Wang, Xiaojing,Zhao, Yue,Strohmer, Dorothee Franziska,et al. The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma[J]. FRONTIERS IN GENETICS,2022,13. |
APA | Wang, Xiaojing,Zhao, Yue,Strohmer, Dorothee Franziska,Yang, Wenjin,Xia, Zhijia,&Yu, Cong.(2022).The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma.FRONTIERS IN GENETICS,13. |
MLA | Wang, Xiaojing,et al."The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma".FRONTIERS IN GENETICS 13(2022). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论