Knowledge Management System of Hefei Institute of Physical Science,CAS
Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer | |
Yu, Dehua1,2; Qi, Simin1,2; Guan, Xiaoqing2; Yu, Wenkai1,2; Yu, Xuefei2; Cai, Maohua1,2; Li, Qinglin2; Wang, Weiyi3; Zhang, Weidong1,4,5; Qin, Jiang-Jiang1,2 | |
2022-03-25 | |
发表期刊 | FRONTIERS IN PHARMACOLOGY |
通讯作者 | Wang, Weiyi(wywang@tio.org.cn) ; Zhang, Weidong(wdzhangy@hotmail.com) ; Qin, Jiang-Jiang(jqin@ucas.ac.cn) |
摘要 | Gastric cancer is a common type of malignant tumor with a relatively poor prognosis and presents a serious threat to global health. Signal Transducer and Activator of Transcription-3 (STAT3) has been strongly implicated in many cancers, and its constitutive activation promotes growth, angiogenesis, inflammation, and immune evasion. Therefore, considerable efforts have been put into developing effective and safe STAT3 inhibitors. In this study, we performed a virtual screening by molecular docking and found that terphenyllin, a marine-derived natural product, directly interacted with STAT3. We further found that terphenyllin inhibited the phosphorylation and activation of STAT3 and decreased the protein levels of STAT3-dependent target genes, including c-Myc and Cyclin D1. Subsequently, we demonstrated that terphenyllin exerted its potent anticancer efficacy against gastric cancer in vitro and in vivo. Terphenyllin concentration-dependently inhibited growth, proliferation, and colony formation and induced cell cycle arrest and apoptosis of gastric cancer cells in vitro. Moreover, terphenyllin treatment suppressed the tumor growth and metastasis in a gastric cancer orthotopic mouse model without notable toxicity in vivo. Taken together, our results indicated that terphenyllin exerts its anticancer activity by inhibiting the STAT3 signaling pathway and may serve as a potent STAT3 inhibitor for gastric cancer treatment. |
关键词 | STAT3 inhibitor natural product gastric cancer terphenyllin |
DOI | 10.3389/fphar.2022.870367 |
关键词[WOS] | MDM2 INHIBITOR ; BREAST-CANCER ; IDENTIFICATION ; DELIVERY ; TARGET |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Program of Zhejiang Provincial TCM Sci-tech Plan[2020ZZ005] ; National Key R and D Program of China[2021YFA0910100] ; National Natural Science Foundation of China[81903842] ; Natural Science Foundation of Zhejiang Province[LR21H280001] ; Natural Science Foundation of Zhejiang Province[LQ22H280022] ; Natural Science Foundation of Fujian Province[2021J01509] ; China Postdoctoral Science Foundation[2021M692873] ; Scientific Research Foundation of Third Institute of Oceanography SOA[2018021] |
项目资助者 | Program of Zhejiang Provincial TCM Sci-tech Plan ; National Key R and D Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province ; Natural Science Foundation of Fujian Province ; China Postdoctoral Science Foundation ; Scientific Research Foundation of Third Institute of Oceanography SOA |
WOS研究方向 | Pharmacology & Pharmacy |
WOS类目 | Pharmacology & Pharmacy |
WOS记录号 | WOS:000792231200001 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/130814 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Wang, Weiyi; Zhang, Weidong; Qin, Jiang-Jiang |
作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 3.Minist Nat Resources, Key Lab Marine Biogenet Resources, Third Inst Oceanog, Xiamen, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res & Shuguan, Shanghai, Peoples R China 5.Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Dehua,Qi, Simin,Guan, Xiaoqing,et al. Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer[J]. FRONTIERS IN PHARMACOLOGY,2022,13. |
APA | Yu, Dehua.,Qi, Simin.,Guan, Xiaoqing.,Yu, Wenkai.,Yu, Xuefei.,...&Qin, Jiang-Jiang.(2022).Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer.FRONTIERS IN PHARMACOLOGY,13. |
MLA | Yu, Dehua,et al."Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer".FRONTIERS IN PHARMACOLOGY 13(2022). |
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