Knowledge Management System of Hefei Institute of Physical Science，CAS
| CDK9 inhibitors in cancer research | |
| Huang, Zhi1,2; Wang, Tianqi1; Wang, Cheng1; Fan, Yan1 | |
| 2022-04-20 | |
| 发表期刊 | RSC MEDICINAL CHEMISTRY
 |
| 通讯作者 | Fan, Yan(yanfan@nankai.edu.cn) |
| 摘要 | Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional elongation. Aberrations in CDK9 activity have been observed in various cancers, which make CDK9 an attractive therapeutic target for cancers. This led to an intensive development of small-molecule CDK9 inhibitors or new emerging strategies, such as proteolysis targeting chimeras (PROTACs). Here, we review the CDK9 modulators in cancer not only for research purposes, but also for therapeutic applications. |
| DOI | 10.1039/d2md00040g |
| 关键词[WOS] | CYCLIN-DEPENDENT KINASE ; POTENT ANTITUMOR-ACTIVITY ; SINGLE-AGENT ACTIVITY ; CYC202 R-ROSCOVITINE ; IN-VITRO ; CELL-CYCLE ; SELICICLIB CYC202 ; MULTIPLE-MYELOMA ; DOWN-REGULATION ; TARGETING CDK9 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[81903099] |
| 项目资助者 | National Natural Science Foundation of China |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| WOS记录号 | WOS:000795942000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/130960 |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Fan, Yan |
| 作者单位 | 1.Nankai Univ, Sch Med, Dept Med Chem, 94 Weijin Rd, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Zhi,Wang, Tianqi,Wang, Cheng,et al. CDK9 inhibitors in cancer research[J]. RSC MEDICINAL CHEMISTRY,2022. |
| APA | Huang, Zhi,Wang, Tianqi,Wang, Cheng,&Fan, Yan.(2022).CDK9 inhibitors in cancer research.RSC MEDICINAL CHEMISTRY. |
| MLA | Huang, Zhi,et al."CDK9 inhibitors in cancer research".RSC MEDICINAL CHEMISTRY (2022). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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