Knowledge Management System of Hefei Institute of Physical Science,CAS
Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy | |
Zhu, Yong-fu1,2; Wang, Shu-Jie3; Zhou, Jie2; Sun, Ye-han1; Chen, You-mou1; Ma, Jia1; Huo, Xing-xing4; Song, Hang5 | |
2022-05-30 | |
发表期刊 | FRONTIERS IN ONCOLOGY |
ISSN | 2234-943X |
通讯作者 | Huo, Xing-xing(hxx0520@ahtcm.edu.cn) ; Song, Hang(hangsong@ahtcm.edu.cn) |
摘要 | N-6-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases ("writers") and demethylases ("erasers") and is recognized and processed by m(6)A-binding proteins ("readers"), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m(6)A and coding and non-coding RNAs and introduce the molecular mechanism of m(6)A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example. |
关键词 | RNA modifications N6-methyladenosine female malignancies molecular mechanisms immunotherapy |
DOI | 10.3389/fonc.2022.897895 |
关键词[WOS] | INHIBITS CELL-PROLIFERATION ; CERVICAL-CANCER ; M(6)A MODIFICATION ; NONCODING RNAS ; METHYLATION ; TRANSLATION ; METASTASIS ; APOPTOSIS ; BINDING ; ROLES |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81802103] ; National Natural Science Foundation of China[81803938] ; Project of High-Level Talents in AHUTCM[2019rcZD001] ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China[2108085Y29] ; Natural Science Research Project of Colleges and Universities in Anhui Province[KJ2021A0557] ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine) ; Zhejiang Chinese Medical University[ZYXZD2019004] |
项目资助者 | National Natural Science Foundation of China ; Project of High-Level Talents in AHUTCM ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China ; Natural Science Research Project of Colleges and Universities in Anhui Province ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine) ; Zhejiang Chinese Medical University |
WOS研究方向 | Oncology |
WOS类目 | Oncology |
WOS记录号 | WOS:000810217800001 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/131322 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Huo, Xing-xing; Song, Hang |
作者单位 | 1.Anhui Univ Chinese Med, Dept Oncol 1, Affiliated Hosp 1, Hefei, Peoples R China 2.Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China 4.Anhui Univ Chinese Med, Affiliated Hosp 1, Expt Ctr Clin Res, Sci Res Dept, Hefei, Peoples R China 5.Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China |
推荐引用方式 GB/T 7714 | Zhu, Yong-fu,Wang, Shu-Jie,Zhou, Jie,et al. Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy[J]. FRONTIERS IN ONCOLOGY,2022,12. |
APA | Zhu, Yong-fu.,Wang, Shu-Jie.,Zhou, Jie.,Sun, Ye-han.,Chen, You-mou.,...&Song, Hang.(2022).Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy.FRONTIERS IN ONCOLOGY,12. |
MLA | Zhu, Yong-fu,et al."Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy".FRONTIERS IN ONCOLOGY 12(2022). |
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