Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study

doi:10.3389/fonc.2022.819756

HFCAS OpenIR

	Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study
	Jiang, Chuner 1,2; Wu, Peng 2,3; He, Xiangming 1,2; Ni, Jianfen 1,2; Ding, Xiaowen 1,2; Xu, Xiaohong 2,4; Wang, Fangzheng 2,5; Zou, Dehong 1,2
	2022-05-30
发表期刊	FRONTIERS IN ONCOLOGY
ISSN	2234-943X
通讯作者	Wang, Fangzheng(wangfz@zjcc.org.cn) ; Zou, Dehong(zoudh1964@126.com)
摘要	Background and ObjectivesReproductive hormones and receptors play crucial roles in breast cancer development and progression. The association between preoperative serum reproductive hormone levels and receptor status in postmenopausal women with breast cancer remains unclear. Therefore, this study investigated the relationship between serum reproductive hormone concentrations and patient characteristics and hormone receptor status among postmenopausal Chinese women with breast cancer. Materials and MethodsThe medical records of 352 postmenopausal breast cancer patients who underwent an operation between October 2007 and October 2010 at the Department of Breast Tumor Surgery of Zhejiang Cancer Hospital were retrospectively evaluated. Serum levels of reproductive hormones were measured before surgery by liquid-chromatography tandem mass spectrometry. Hormone receptor levels were measured by an immunohistochemical assay using a mouse monoclonal antibody. The associations between serum hormone concentrations and hormone receptors were investigated by analysis of covariance. ResultsIn this patient cohort, the serum level of luteinizing hormone (LH) declined with PMP duration. The median LH concentration was significantly higher in patients within 5 years of PMP than that in patients with PMP duration exceeding 5 years (23 vs. 18.32 mIU/ml, P <.0001). Significantly more patients with strong estrogen receptor (ER) or progesterone receptor (PR) expression had postmenopausal durations of less than 5 years compared to those with postmenopausal durations greater than 5 years (103 vs. 61 cases, P = .019; 93 vs. 46 cases, P = .0005). While most patients either lacked (97.1%) or co-expressed (84.3%) ER and PR, some patients expressed either ER or PR alone. ER and PR expression were negatively associated with receptor-tyrosine kinase erbB-2 (HER2) expression in postmenopausal patients with breast cancer. Meanwhile, increased ER and PR expression were associated with decreased serum levels of LH or follicle-stimulating hormone (FSH). ConclusionDecreased serum LH and FSH levels were associated with increased ER and PR expressions and decreased HER2 expression in postmenopausal patients with breast cancer.
关键词	breast cancer postmenopausal reproductive hormones estrogen receptor progesterone receptor HER2 receptor
DOI	10.3389/fonc.2022.819756
关键词[WOS]	PROGESTERONE-RECEPTORS ; ESTROGEN ; STATISTICS ; IMMUNOHISTOCHEMISTRY ; MARKERS ; DISEASE ; RISK
收录类别	SCI
语种	英语
资助项目	Medical and Health Science and Technology Program of Zhejiang Province[2020KY084] ; Medical and Health Science and Technology Program of Zhejiang Province[2019KY041] ; Medical and Health Science and Technology Program of Zhejiang Province[2011RCA014] ; Medical and Health Science and Technology Program of Zhejiang Province[2006A016] ; Medical and Health Science and Technology Program of Zhejiang Province[2005B012] ; National Natural Science Foundation of Zhejiang Province of China[LY15H1800012015] ; National Natural Science Foundation of China[81502646] ; National Natural Science Foundation of China[81502647]
项目资助者	Medical and Health Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of Zhejiang Province of China ; National Natural Science Foundation of China
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000811323700001
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/131342
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Fangzheng; Zou, Dehong
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Breast Tumor Surg, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Pathol Dept, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Clin Lab, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Chuner,Wu, Peng,He, Xiangming,et al. Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study[J]. FRONTIERS IN ONCOLOGY,2022,12.
APA	Jiang, Chuner.,Wu, Peng.,He, Xiangming.,Ni, Jianfen.,Ding, Xiaowen.,...&Zou, Dehong.(2022).Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study.FRONTIERS IN ONCOLOGY,12.
MLA	Jiang, Chuner,et al."Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study".FRONTIERS IN ONCOLOGY 12(2022).